Glutaredoxin 2 Antikörper (Middle Region)

Produktnummer ABIN2787395

Produktdetails anti-Glutaredoxin 2 Antikörper

Target: Glutaredoxin 2 (GRX2)

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Glutaredoxin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: NVNYKVVELD LLEYGNQFQD ALYKMTGERT VPRIFVNGTF IGGATDTHRL H

Homologie: Cow: 86%, Dog: 86%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 86%, Sheep: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against GLRX2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GLRX2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 164 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Glutaredoxin 2

Target: Glutaredoxin 2 (GRX2)

Andere Bezeichnung: GLRX2 (GRX2 Produkte)

Synonyme: ECK1049 antikoerper, JW1051 antikoerper, CGI-133 antikoerper, GRX2 antikoerper, 1700010P22Rik antikoerper, AI645710 antikoerper, Grx2 antikoerper, glutaredoxin 2 (Grx2) antikoerper, glutaredoxin Grx2 antikoerper, thioredoxin antikoerper, glutaredoxin 2 antikoerper, glutaredoxin 2 (thioltransferase) antikoerper, grxB antikoerper, grx2 antikoerper, AF_RS10790 antikoerper, GLRX2 antikoerper, Glrx2 antikoerper

Hintergrund: GLRX2 is a glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress.GLRX2 is involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress.GLRX2 acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides.GLRX2 can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions.GLRX2 efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression of GLRX2 decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
Alias Symbols: GRX2, bA101E13.1, CGI-133
Protein Interaction Partner: BAG3, TXNRD1,
Protein Size: 164

Molekulargewicht: 18 kDa

Gen-ID: 51022

NCBI Accession: NM_197962, NP_932066

UniProt: Q9NS18

Pathways: Cell RedoxHomeostasis