ATF5 Antikörper (Middle Region)

Produktnummer ABIN2787491

Produktdetails anti-ATF5 Antikörper

Target: ATF5 (Activating Transcription Factor 5 (ATF5))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Zebrafisch (Danio rerio), Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATF5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LPPPQQPPPP SPPQPSRLAP YPHPATTRGD RKQKKRDQNK SAALRYRQRK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against ATF5. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ATF5

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 282 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-ATF5 Antikörper (ABIN2787491)

Wei, Jiang, Liu, Zhou, Chen, Zhang, Zong, Yun, Gu: "Cdc34-mediated degradation of ATF5 is blocked by cisplatin." in: The Journal of biological chemistry, Vol. 283, Issue 27, pp. 18773-81, (2008) (PubMed).

Details zu ATF5

Target: ATF5 (Activating Transcription Factor 5 (ATF5))

Andere Bezeichnung: ATF5 (ATF5 Produkte)

Synonyme: ATF5 antikoerper, atfx antikoerper, hmfn0395 antikoerper, ATFX antikoerper, HMFN0395 antikoerper, AFTA antikoerper, Atf7 antikoerper, Atfx antikoerper, ODA-10 antikoerper, atf5 antikoerper, activating transcription factor 5 antikoerper, activating transcription factor 5, gene 2 S homeolog antikoerper, ATF5 antikoerper, atf5 antikoerper, Atf5 antikoerper, atf5.2.S antikoerper

Hintergrund: ATF5 belongs to the bZIP family. It is transcriptional activator which binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4. Loss of ATF5 is associated with hepatocellular carcinoma.
Alias Symbols: ATFX, FLJ34666, HMFN0395
Protein Interaction Partner: CEBPE, CEBPA, GIT2, ATXN1, EP300, CCND3, GABBR2, DISC1, GABBR1, CEBPG, CDC34, TRIB3, UBC, CD34,
Protein Size: 282

Molekulargewicht: 31 kDa

Gen-ID: 22809

NCBI Accession: NM_012068, NP_036200

UniProt: B3KND3

Pathways: Myometrial Relaxation and Contraction