MED14 Antikörper (Middle Region)

Produktnummer ABIN2787568

Produktdetails anti-MED14 Antikörper

Target: MED14 (Mediator Complex Subunit 14 (MED14))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MED14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)

Sequenz: AADREDSPAM ALLLQQFKEN IQDLVFRTKT GKQTRTNAKR KLSDDPCPVE

Homologie: Human: 100%, Mouse: 79%, Rabbit: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against MED14. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MED14

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1454 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MED14

Target: MED14 (Mediator Complex Subunit 14 (MED14))

Andere Bezeichnung: MED14 (MED14 Produkte)

Hintergrund: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.
Alias Symbols: CRSP150, CRSP2, CSRP, CXorf4, DRIP150, EXLM1, MGC104513, RGR1, TRAP170
Protein Interaction Partner: UBC, HECW2, CDK8, CDK19, MED12, ESR1, MED19, MED26, PPARG, FBXW7, EPAS1, MED11, MED8, MED29, MED18, MED4, PPP6R1, MED16, MED13, MED24, MED27, MED17, MED21, MED1, CTDP1, SREBF1, DCTN1, ACTN2, ACTN1, MED10, UACA, NECAB2, MED25, MED15, CRSP5, MED7, MED23, VD
Protein Size: 1454

Molekulargewicht: 160 kDa

Gen-ID: 9282

NCBI Accession: NM_004229, NP_004220

UniProt: O60244

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha