H2AFY Antikörper (Middle Region)

Produktnummer ABIN2787622

Produktdetails anti-H2AFY Antikörper

Target: H2AFY (H2A Histone Family, Member Y (H2AFY))

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Pferd, Hund, Meerschweinchen, Kaninchen, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser H2AFY Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: PVSKKAGGKK GARKSKKQGE VSKAASADST TEGTPADGFT VLSTKSLFLG

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against H2AFY. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human H2AFY

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 371 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu H2AFY

Target: H2AFY (H2A Histone Family, Member Y (H2AFY))

Andere Bezeichnung: H2AFY (H2AFY Produkte)

Synonyme: H2A.y antikoerper, H2A/y antikoerper, H2AF12M antikoerper, H2AFJ antikoerper, MACROH2A1.1 antikoerper, mH2A1 antikoerper, macroH2A1.2 antikoerper, mH2a1 antikoerper, macroH2A1 antikoerper, wu:fa93c12 antikoerper, zgc:136891 antikoerper, h2a.y antikoerper, h2a/y antikoerper, h2af12m antikoerper, h2afj antikoerper, macroh2a antikoerper, mh2a1 antikoerper, core histone macro-H2A.1 antikoerper, H2A histone family, member Y antikoerper, H2A histone family member Y antikoerper, H2A histone family member Y L homeolog antikoerper, LOC100230612 antikoerper, H2AFY antikoerper, LOC481514 antikoerper, H2afy antikoerper, h2afy antikoerper, h2afy.L antikoerper

Hintergrund: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. H2AFY is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alias Symbols: H2A.y, H2A/y, H2AF12M, H2AFJ, MACROH2A1.1, mH2A1, macroH2A1.2
Protein Interaction Partner: ERICH2, UBC, SUMO2, SUMO3, HIST1H3A, H3F3A, SUZ12, EED, RNF2, EZH2, BMI1, SRPK1, LMNA, ATF2, FN1, HIST1H3B, CENPA, APP, CBX5, CBX3, DIDO1, UBD, ATXN1L, NEDD8, ERBB2, SUMO1, HDGF, HDAC2, HDAC1, PARP1, tat, CUL3, SPOP, WDR77, PHF14, DEK, XRCC5, TOP1, RAN, H
Protein Size: 371

Molekulargewicht: 39 kDa

Gen-ID: 9555

NCBI Accession: NM_001040158, NP_001035248

UniProt: O75367