CBX2 Antikörper (Middle Region)

Produktnummer ABIN2787656

Produktdetails anti-CBX2 Antikörper

Target: CBX2 (Chromobox Homolog 2 (CBX2))

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Rind (Kuh), Pferd, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CBX2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SDSDPDSASP PSTGQNPSVS VQTSQDWKPT RSLIEHVFVT DVTANLITVT

Homologie: Cow: 86%, Horse: 93%, Human: 100%, Pig: 79%, Rat: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against CBX2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CBX2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 532 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CBX2

Target: CBX2 (Chromobox Homolog 2 (CBX2))

Andere Bezeichnung: CBX2 (CBX2 Produkte)

Synonyme: cbx2 antikoerper, M33 antikoerper, pc1 antikoerper, wu:fd20e09 antikoerper, zgc:103563 antikoerper, MOD2 antikoerper, pc antikoerper, CDCA6 antikoerper, SRXY5 antikoerper, cdca6 antikoerper, m33 antikoerper, chromobox 2 antikoerper, chromobox homolog 2 (Drosophila Pc class) antikoerper, chromobox 2 L homeolog antikoerper, cbx2 antikoerper, CBX2 antikoerper, Cbx2 antikoerper, cbx2.L antikoerper

Hintergrund: CBX2 Contains 1 A.T hook DNA-binding domain and 1 chromo domain. CBX2 is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Alias Symbols: CDCA6, M33, MGC10561, SRXY5
Protein Interaction Partner: KRTAP10-3, KRTAP10-1, KRTAP10-9, KRTAP10-7, RBMY1F, DHX57, KRTAP2-4, RBMY1A1, RNF2, BMI1, MDFI, SOX2, GTF2I, PHC2, CSNK2B, CSNK2A2, CSNK2A1, CENPE, PARP1, CCDC158, DIS3L2, HIST4H4, CBX2, PARP12, RNF213, ZKSCAN7, DCAF6, KDM3A, MYCBP2, ANKRD26, PSME3, TRANK
Protein Size: 532

Molekulargewicht: 56 kDa

Gen-ID: 84733

NCBI Accession: NM_005189, NP_005180

UniProt: Q14781