Calpain S1 Antikörper (Middle Region)

Produktnummer ABIN2787678

Produktdetails anti-Calpain S1 Antikörper

Target: Calpain S1 (CAPNS1) (Calpain, Small Subunit 1 (CAPNS1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Kaninchen, Hund, Meerschweinchen, Pferd, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Calpain S1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: RRYSDESGNM DFDNFISCLV RLDAMFRAFK SLDKDGTGQI QVNIQEWLQL

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CAPNS1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CAPNS1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 268 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Calpain S1 Antikörper (ABIN2787678)

Kulkarni, Liu, Qi, Zhu, Klinke, Liu: "Differential proteomic analysis of caveolin-1 KO cells reveals Sh2b3 and Clec12b as novel interaction partners of caveolin-1 and Capns1 as a potential mediator of caveolin-1-induced apoptosis." in: The Analyst, Vol. 138, Issue 22, pp. 6986-96, (2013) (PubMed).

Details zu Calpain S1

Target: Calpain S1 (CAPNS1) (Calpain, Small Subunit 1 (CAPNS1))

Andere Bezeichnung: CAPNS1 (CAPNS1 Produkte)

Synonyme: 30K antikoerper, CALPAIN4 antikoerper, CANP antikoerper, CANPS antikoerper, CAPN4 antikoerper, CDPS antikoerper, CSS1 antikoerper, Capn4 antikoerper, CAPNS1 antikoerper, Capa-4 antikoerper, Capa4 antikoerper, D7Ertd146e antikoerper, MGC84330 antikoerper, capns1 antikoerper, cb616 antikoerper, wu:fb81g08 antikoerper, wu:fl09e04 antikoerper, zgc:110603 antikoerper, calpain small subunit 1 antikoerper, calpain, small subunit 1 antikoerper, calpain, small subunit 1 L homeolog antikoerper, calpain, small subunit 1 a antikoerper, CAPNS1 antikoerper, Capns1 antikoerper, capns1.L antikoerper, capns1a antikoerper

Hintergrund: Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene.
Alias Symbols: 30K, CALPAIN4, CANP, CANPS, CAPN4, CDPS, CSS1
Protein Interaction Partner: AGTRAP, HUWE1, NEDD1, TUBGCP2, TUBGCP3, CDC20, UBC, OGFOD1, STK26, ISOC1, DCPS, MAT2B, PROSC, FERMT2, YWHAQ, PDIA4, YWHAZ, YWHAH, YWHAG, YWHAE, PTMA, PPP1CA, PAK2, PAFAH1B1, MYO1E, MAT2A, GNAI3, GAPDH, EIF5, TBCB, ALDH7A1, ASNS, APEX1, ADRB2, PPARGC1A, VC
Protein Size: 268

Molekulargewicht: 29 kDa

Gen-ID: 826

NCBI Accession: NM_001003962, NP_001003962

UniProt: P04632

Pathways: Apoptose