alpha KGDHC Antikörper (N-Term)

Produktnummer ABIN2787780

Produktdetails anti-alpha KGDHC Antikörper

Target: alpha KGDHC (alphaKGDHC) (alpha Ketoglutarate Dehydrogenase (alphaKGDHC))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Pferd, Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser alpha KGDHC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MFHLRTCAAK LRPLTASQTV KTFSQNRPAA ARTFQQIRCY SAPVAAEPFL

Homologie: Cow: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against OGDH. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human OGDH

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 427 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu alpha KGDHC

Target: alpha KGDHC (alphaKGDHC) (alpha Ketoglutarate Dehydrogenase (alphaKGDHC))

Andere Bezeichnung: OGDH (alphaKGDHC Produkte)

Synonyme: AKGDH antikoerper, E1k antikoerper, OGDC antikoerper, 2210403E04Rik antikoerper, 2210412K19Rik antikoerper, AA409584 antikoerper, d1401 antikoerper, mKIAA4192 antikoerper, oxoglutarate dehydrogenase antikoerper, oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) antikoerper, OGDH antikoerper, Ogdh antikoerper

Hintergrund: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitocondrial matrix and uses thiamine pyrophosphate as a cofactor. A congential deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia.
Alias Symbols: AKGDH, E1k, OGDC
Protein Interaction Partner: MDM2, UBC, SUMO1, NEDD8, CPSF7, MRPL38, MRPL41, TSR1, MRPS2, MRPL15, MRPL13, SCFD1, PDHX, SSBP1, SUMO2, PDHB, PDHA1, DLST, DLAT, DHODH, ISG15, USP13, PLSCR1, DLD,
Protein Size: 427

Molekulargewicht: 47 kDa

Gen-ID: 4967

NCBI Accession: NM_001003941, NP_001003941

UniProt: Q96DD3