Caspase 4 Antikörper (Middle Region)
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- Target Alle Caspase 4 (CASP4) Antikörper anzeigen
- Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))
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Bindungsspezifität
- Middle Region
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Reaktivität
- Human, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Caspase 4 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- GILEGICGTV HDEKKPDVLL YDTIFQIFNN RNCLSLKDKP KVIIVQACRG
- Homologie
- Human: 100%, Rat: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against CASP4. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human CASP4
- Top Product
- Discover our top product CASP4 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 377 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))
- Andere Bezeichnung
- CASP4 (CASP4 Produkte)
- Synonyme
- ICE(rel)II antikoerper, ICEREL-II antikoerper, ICH-2 antikoerper, Mih1/TX antikoerper, TX antikoerper, Casp11 antikoerper, CASP13 antikoerper, CASP1 antikoerper, CASP4 antikoerper, Caspl antikoerper, ich-3 antikoerper, Casp4 antikoerper, caspase 4 antikoerper, caspase 4, apoptosis-related cysteine peptidase antikoerper, caspase-4 antikoerper, CASP4 antikoerper, Casp4 antikoerper, LOC100731032 antikoerper
- Hintergrund
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This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
Alias Symbols: ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX
Protein Interaction Partner: MYH9, ELF4, APP, TRAF6, PLA2G4A, NOD1, CASP14, CASP4, APAF1, SERPINB9, CASP10, IL18, CASP3, IL1B, DSP, PSEN1, IL37, CASP8, CASP1, XIAP, MYCBPAP, SLC25A22, SRPRB, CTNNBIP1, DNAAF5, MTHFD1L, UFL1, GCN1L1, SMC2, NUP93, SMC3, SMC1A, USP9X, VDAC3, PSMB1, MSH6,
Protein Size: 377 - Molekulargewicht
- 10 kDa
- Gen-ID
- 837
- NCBI Accession
- NM_001225, NP_001216
- UniProt
- P49662
- Pathways
- Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity
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