CRY1 Antikörper (N-Term)

Produktnummer ABIN2788200

Produktdetails anti-CRY1 Antikörper

Target: CRY1 (Cryptochrome 1 (Photolyase-Like) (CRY1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Pferd, Schaf, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CRY1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: KRFQTLISKM EPLEIPVETI TSEVIEKCTT PLSDDHDEKY GVPSLEELGF

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against CRY1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CRY1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 586 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-CRY1 Antikörper (ABIN2788200)

Currie, Doherty, Sillar: "Deep-brain photoreception links luminance detection to motor output in Xenopus frog tadpoles." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 21, pp. 6053-8, (2016) (PubMed).

Details zu CRY1

Target: CRY1 (Cryptochrome 1 (Photolyase-Like) (CRY1))

Andere Bezeichnung: CRY1 (CRY1 Produkte)

Synonyme: cry1-A antikoerper, CRY1 antikoerper, cry2 antikoerper, phll1 antikoerper, xCRY1 antikoerper, PHLL1 antikoerper, AU020726 antikoerper, AU021000 antikoerper, Phll1 antikoerper, ATCRY1 antikoerper, BLU1 antikoerper, BLUE LIGHT UNINHIBITED 1 antikoerper, CRYPTOCHROME 1 APOPROTEIN (BLUE LIGHT PHOTORECEPTOR antikoerper, ELONGATED HYPOCOTYL 4 antikoerper, HY4 antikoerper, OOP2 antikoerper, OUT OF PHASE 2 antikoerper, T3H13.14 antikoerper, T3H13_14 antikoerper, cryptochrome 1 antikoerper, cryptochrome circadian clock 1 L homeolog antikoerper, cryptochrome circadian regulator 1 antikoerper, cryptochrome circadian clock 1 antikoerper, Cryptochrome-1 antikoerper, cryptochrome 1 antikoerper, cryptochrome 1 (photolyase-like) antikoerper, cry1.L antikoerper, CRY1 antikoerper, cry1 antikoerper, siu50817b antikoerper, Cry1 antikoerper

Hintergrund: CRY1 is the blue light-dependent regulator of the circadian feedback loop. CRY1 inhibits CLOCK NPAS2-ARNTL E box-mediated transcription. CRY1 acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. CRY1 has no photolyase activity. CRY1 is capable of translocating circadian clock core proteins such as PER proteins to the nucleus. CRY1 may inhibit CLOCK NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL.
Alias Symbols: PHLL1
Protein Interaction Partner: PER2, FBXL3, FBXL21, PLSCR1, BTRC, CUL1, SKP1, CSNK1E, LTBP4, UBC, SNRPD3, GRN, USP2, Timeless, Cry1, KRTAP4-12, PER3, MDFI, CBLB, ARNTL, PER1, TRAF2,
Protein Size: 586

Molekulargewicht: 64 kDa

Gen-ID: 1407

NCBI Accession: NM_004075, NP_004066

UniProt: Q16526

Pathways: Response to Water Deprivation, Proton Transport