CTSC Antikörper (Middle Region)

Produktnummer ABIN2788336

Produktdetails anti-CTSC Antikörper

Target: CTSC (Cathepsin C (CTSC))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Rind (Kuh), Hund, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CTSC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: WTATTYMEYE TLTLGDMIRR SGGHSRKIPR PKPAPLTAEI QQKILHLPTS

Homologie: Cow: 86%, Dog: 79%, Horse: 86%, Human: 100%, Mouse: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against CTSC. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CTSC

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 463 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CTSC

Target: CTSC (Cathepsin C (CTSC))

Andere Bezeichnung: CTSC (CTSC Produkte)

Hintergrund: CTSC is a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in CTSC have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.
Alias Symbols: CPPI, DPP1, DPPI, HMS, JP, JPD, PALS, PLS, DPP-I
Protein Interaction Partner: SUMO1, UBC, NEDD8, ARMC9, ANKMY2, ARIH1, UBA2, ADSL, FBXO6, XRN2, CAPN1, CD81, CTSC, CTSL,
Protein Size: 463

Molekulargewicht: 8 kDa

Gen-ID: 1075

NCBI Accession: NM_001814, NP_001805

UniProt: P53634