DDB2 Antikörper (C-Term)

Produktnummer ABIN2788357

Produktdetails anti-DDB2 Antikörper

Target: DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Pferd, Kaninchen, Rind (Kuh), Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DDB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: IVVGRYPDPN FKSCTPYELR TIDVFDGNSG KMMCQLYDPE SSGISSLNEF

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 79%, Rabbit: 93%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against DDB2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DDB2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 427 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DDB2

Target: DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))

Andere Bezeichnung: DDB2 (DDB2 Produkte)

Synonyme: 2610043A19Rik antikoerper, si:dkey-45f10.3 antikoerper, DDBB antikoerper, UV-DDB2 antikoerper, damage specific DNA binding protein 2 antikoerper, damage-specific DNA binding protein 2 antikoerper, DDB2 antikoerper, ddb2 antikoerper, Ddb2 antikoerper

Hintergrund: This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities.
Alias Symbols: DDBB, FLJ34321, UV-DDB2
Protein Interaction Partner: CUL4A, CUL4B, XPC, PARP1, UBC, SUMO1, SMEK1, COPG1, POP1, PSMB4, PSMB1, PSMA5, SEPT2, ARCN1, SUMO2, DDB1, USP24, USP53, RFWD2, COPS4, COPS6, COPS2, COPS3, XPA, TOP1, GRK5, EP300, COPS7A, COPS5, COPS8, RBX1, GPS1, E2F1, DDB2, CUL5, NEDD8, DCLRE1C, vpr, ERC
Protein Size: 427

Molekulargewicht: 48 kDa

Gen-ID: 1643

NCBI Accession: NM_000107, NP_000098

UniProt: Q92466

Pathways: DNA Reparatur