EIF3A Antikörper (C-Term)

Produktnummer ABIN2788872

Produktdetails anti-EIF3A Antikörper

Target: EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Kaninchen, Rind (Kuh), Hund, Pferd, Zebrafisch (Danio rerio), Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EIF3A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: PPALSRDRER DRDREREGEK EKASWRAEKD RESLRRTKNE TDEDGWTTVR

Homologie: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against EIF3A. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1382 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu EIF3A

Target: EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A))

Andere Bezeichnung: EIF3A (EIF3A Produkte)

Hintergrund: EIF3A is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Alias Symbols: EIF3, EIF3S10, KIAA0139, P167, TIF32, eIF3-p170, eIF3-theta, p180, p185
Protein Interaction Partner: UBC, REL, TFIP11, WWP2, SUMO2, STAU1, LGR4, WWOX, EED, SHFM1, RNF2, EIF3CL, YTHDF2, LARP1, NUDT21, EIF3C, DYNC1I2, RPS26, RPS25, RPS23, RPS20, RPS18, RPS12, RPS10, RPS9, RPS3A, RPS3, FBXO6, TARDBP, EIF3D, UBD, ICAM1, CD81, RIOK2, IGSF8, BBS4, BBS1, gag-po
Protein Size: 1382

Molekulargewicht: 152 kDa

Gen-ID: 8661

NCBI Accession: NM_003750, NP_003741

UniProt: Q14152

Pathways: Ribonucleoprotein Complex Subunit Organization