BRE Antikörper (C-Term)
-
- Target Alle BRE Antikörper anzeigen
- BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))
-
Bindungsspezifität
- C-Term
-
Reaktivität
- Human, Maus, Ratte, Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio), Rind (Kuh), Hund
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser BRE Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequenz
- YHFTNSGQLY SQAQKNYPYS PRWDGNEMAK RAKAYFKTFV PQFQEAAFAN
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against BRE. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Top Product
- Discover our top product BRE Primärantikörper
-
-
- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
-
Antigen size: 383 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Target
- BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))
- Andere Bezeichnung
- BRE (BRE Produkte)
- Synonyme
- brcc4 antikoerper, brcc45 antikoerper, BRE antikoerper, LOC100231620 antikoerper, BRCC4 antikoerper, BRCC45 antikoerper, 6030405P19Rik antikoerper, AI429776 antikoerper, B830038C02Rik antikoerper, im:7141046 antikoerper, zgc:110368 antikoerper, BRISC and BRCA1 A complex member 2 antikoerper, brain and reproductive organ-expressed (TNFRSF1A modulator) antikoerper, BRISC and BRCA1 A complex member 2 L homeolog antikoerper, babam2 antikoerper, BABAM2 antikoerper, Babam2 antikoerper, BRE antikoerper, babam2.L antikoerper
- Hintergrund
-
BRE is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. BRE probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. BRE may play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. BRE may also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway anf regulate TNF-alpha signaling through its interactions with TNFRSF1A, however these effects may be indirect.
Alias Symbols: BRCC4, BRCC45
Protein Interaction Partner: FAM175B, UBC, BABAM1, AKAP2, TFG, OPTN, HNRNPA2B1, SUMO2, PAXIP1, MDC1, BRCA1, GRB2, UBD, GFI1B, UIMC1, BRCC3, FAM175A, NCOA3, COPS5, SUMO1, TNFRSF1A, FAS, MMS19, UGGT2, TMX3, DHRS7B, FKBP8, TTC28, ATG2A, SLC25A13, LRPPRC, USP7, SSR3, SHMT2, RPN2, PHB, UB
Protein Size: 383 - Molekulargewicht
- 43 kDa
- Gen-ID
- 9577
- NCBI Accession
- NM_199194, NP_954664
- UniProt
- Q9NXR7
- Pathways
- Positive Regulation of Response to DNA Damage Stimulus
-