Merlin Antikörper (C-Term)

Produktnummer ABIN2789402

Produktdetails anti-Merlin Antikörper

Target: Merlin (NF2) (Neurofibromin 2 (NF2))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio), Hund, Rind (Kuh), Pferd, Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Merlin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MAEESERRAK EADQLKQDLQ EAREAERRAK QKLLEIATKP TYPPMNPIPA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against NF2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 507 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Merlin Antikörper (ABIN2789402)

Vasilyeva, Murzina, Kireev, Pivovarov: "Influence of Membrane Receptor Lateral Diffusion on the Short-Term Depression of Acetylcholine-Induced Current in Helix Neurons." in: Cellular and molecular neurobiology, (2017) (PubMed).

Details zu Merlin

Target: Merlin (NF2) (Neurofibromin 2 (NF2))

Andere Bezeichnung: NF2 (NF2 Produkte)

Synonyme: ACN antikoerper, BANF antikoerper, SCH antikoerper, NF2 antikoerper, merlin antikoerper, zgc:194620 antikoerper, zgc:194631 antikoerper, NF2a antikoerper, nf2 antikoerper, neurofibromin 2 antikoerper, neurofibromin 2a (merlin) antikoerper, neurofibromin 2b (merlin) antikoerper, neurofibromin 2 (merlin) S homeolog antikoerper, NF2 antikoerper, Nf2 antikoerper, nf2a antikoerper, nf2b antikoerper, nf2.S antikoerper

Hintergrund: This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development, in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.
Alias Symbols: ACN, BANF, SCH
Protein Interaction Partner: VPRBP, CD44, UBC, KDM1A, AMOTL2, YAP1, PPP1R8, UBD, CCNB1IP1, HGS, CUL4A, DDB1, GPS1, WWC1, PYGO2, AMOT, SCHIP1, SGSM3, NF2, TSC1, TARBP2, SLC9A3R1, PAK1, XPO1, PXN, SDCBP, RALGDS, SPTBN1, ERBB2, ITGB1, EZR, CTNNB1, AGAP2, AKT1, RIT1, ARHGAP32, SOS1, MED2
Protein Size: 507

Molekulargewicht: 56 kDa

Gen-ID: 4771

NCBI Accession: NM_181830, NP_861968

Pathways: Cell-Cell Junction Organization