VKORC1 Antikörper (N-Term)

Produktnummer ABIN2789450

Produktdetails anti-VKORC1 Antikörper

Target: VKORC1 (Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Hund, Meerschweinchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VKORC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: LHVKAARARD RDYRALCDVG TAISCSRVFS SRLPADTLGL CPDAAELPGV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against VKORC1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of VKORC1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 92 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu VKORC1

Target: VKORC1 (Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1))

Andere Bezeichnung: VKORC1 (VKORC1 Produkte)

Hintergrund: Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described.
Alias Symbols: EDTP308, FLJ00289, IMAGE3455200, MGC2694, MST134, MST576, VKCFD2, VKOR
Protein Interaction Partner: UBC, ILK, ZMYM6NB, TMEM242, SNORA12, TMEM256, ZCCHC24, METTL7B, SPTSSA, VKORC1L1, CCDC167, CCDC12, TMEM45B, KCNK17, JAGN1, SERP1, PPA2, TRAM1, TREX1, YIF1A, EBP, ARL6IP5, PROCR, IFITM3, ATP6AP2, BCAP31, PDIA6, HDAC6, HOMER2, VAPB, CLDN10, DPM2, REEP5, TF,
Protein Size: 92

Molekulargewicht: 10 kDa

Gen-ID: 79001

NCBI Accession: NM_206824, NP_996560

UniProt: Q9BQB6