SOCS2 Antikörper (C-Term)

Produktnummer ABIN2789498

Produktdetails anti-SOCS2 Antikörper

Target: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Schwein, Hund, Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SOCS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: KQFDSVVHLI DYYVQMCKDK RTGPEAPRNG TVHLYLTKPL YTSAPSLQHL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SOCS2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 198 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SOCS2

Target: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Andere Bezeichnung: SOCS2 (SOCS2 Produkte)

Synonyme: CIS2 antikoerper, Cish2 antikoerper, SOCS-2 antikoerper, SSI-2 antikoerper, SSI2 antikoerper, STATI2 antikoerper, Cish1 antikoerper, Socs-1 antikoerper, Socs-2 antikoerper, si:dkey-202b22.1 antikoerper, socs2 antikoerper, cis2 antikoerper, ssi2 antikoerper, cish2 antikoerper, ssi-2 antikoerper, socs-2 antikoerper, stati2 antikoerper, 8030460M17 antikoerper, AI527257 antikoerper, AW108012 antikoerper, D130043N08Rik antikoerper, JAB antikoerper, hg antikoerper, Cradd antikoerper, Socs2 antikoerper, suppressor of cytokine signaling 2 antikoerper, suppressor of cytokine signaling 1 antikoerper, death domain-containing protein CRADD antikoerper, suppressor of cytokine signaling 2 S homeolog antikoerper, SOCS2 antikoerper, Socs1 antikoerper, Socs2 antikoerper, socs2 antikoerper, LOC100716104 antikoerper, socs2.S antikoerper

Hintergrund: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.
Alias Symbols: CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2
Protein Interaction Partner: Tceb1, CUL5, UBC, FLT3, ARFIP2, TPD52, PLA2G1B, BMI1, SOCS3, LCK, GHR, CCNC, RYBP, PTK2B, RNF7, TCEB2, EPOR, PTK2, PRLR, INSR, IGF1R, SOCS1,
Protein Size: 198

Molekulargewicht: 22 kDa

Gen-ID: 8835

NCBI Accession: NM_003877, NP_003868

UniProt: O14508

Pathways: JAK-STAT Signalweg, Response to Growth Hormone Stimulus