Neural Wiskott-Aldrich syndrome protein (WASL) (Middle Region) Antikörper

Produktnummer ABIN2789523

Produktdetails

Target: Neural Wiskott-Aldrich syndrome protein (WASL)

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Pferd, Schwein, Kaninchen, Rind (Kuh), Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: ISHTKEKKKG KAKKKRLTKA DIGTPSNFQH IGHVGWDPNT GFDLNNLDPE

Homologie: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against WASL. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 505 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Antigendetails

Target: Neural Wiskott-Aldrich syndrome protein (WASL)

Andere Bezeichnung: WASL (WASL Produkte)

Synonyme: N-WASP antikoerper, TRS4 antikoerper, NWASP antikoerper, WASPB antikoerper, 2900021I12Rik antikoerper, 3110031I02Rik antikoerper, zgc:158395 antikoerper, n-wasp antikoerper, nwasp antikoerper, wasl antikoerper, zgc:55478 antikoerper, zgc:77237 antikoerper, Wiskott-Aldrich syndrome-like antikoerper, Wiskott-Aldrich syndrome like antikoerper, Wiskott-Aldrich syndrome-like (human) antikoerper, Wiskott-Aldrich syndrome-like a antikoerper, Wiskott-Aldrich syndrome like L homeolog antikoerper, Wiskott-Aldrich syndrome-like b antikoerper, Wasl antikoerper, WASL antikoerper, wasla antikoerper, wasl.L antikoerper, waslb antikoerper

Hintergrund: The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes.
Alias Symbols: DKFZp779G0847, MGC48327, N-WASP, NWASP
Protein Interaction Partner: RHOJ, ARPC3, RNF8, NCK2, WIPF1, SDCBP, PTK6, GRB2, IQGAP1, WWOX, SNX9, APBB1, PRPF40A, FNBP1L, FNBP1, TRIP10, PSTPIP1, ACTG1, SORBS3, ACTR2, ACTR3, LCK, CDC42, RPL7AP66, ZNF395, BAIAP2, ARPC1B, FCHSD2, IPO5, HP, HSP90AB1, HSP90AA1, SRC, WASF2, APP, WIPF2,
Protein Size: 505

Molekulargewicht: 56 kDa

Gen-ID: 8976

NCBI Accession: NM_003941, NP_003932

UniProt: O00401