WISP1 Antikörper (Middle Region)

Produktnummer ABIN2789653

Produktdetails anti-WISP1 Antikörper

Target: WISP1 (WNT1 Inducible Signaling Pathway Protein 1 (WISP1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Schwein, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WISP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: VRPPRLWCPH PRRVSIPGHC CEQWVCEDDA KRPRKTAPRD TGAFDAVGEV

Homologie: Cow: 92%, Human: 100%, Pig: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against WISP1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 367 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu WISP1

Target: WISP1 (WNT1 Inducible Signaling Pathway Protein 1 (WISP1))

Andere Bezeichnung: WISP1 (WISP1 Produkte)

Synonyme: CCN4 antikoerper, WISP1c antikoerper, WISP1i antikoerper, WISP1tc antikoerper, WISP-1 antikoerper, WISP1 antikoerper, si:ch211-38f10.2 antikoerper, AW146261 antikoerper, Elm1 antikoerper, zgc:172276 antikoerper, WNT1 inducible signaling pathway protein 1 antikoerper, WNT1 inducible signaling pathway protein 1a antikoerper, WNT1-inducible-signaling pathway protein 1-like antikoerper, WNT1 inducible signaling pathway protein 1b antikoerper, WISP1 antikoerper, wisp1a antikoerper, Wisp1 antikoerper, LOC100627044 antikoerper, wisp1b antikoerper

Hintergrund: This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase.
Alias Symbols: CCN4, WISP1c, WISP1i, WISP1tc
Protein Interaction Partner: BGN, DCN, UGGT1,
Protein Size: 367

Molekulargewicht: 38 kDa

Gen-ID: 8840

NCBI Accession: NM_003882, NP_003873

UniProt: O95388

Pathways: WNT Signalweg, Growth Factor Binding