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DEF6 Antikörper (C-Term)
DEF6
Reaktivität: Human, Maus, Ratte, Hund, Schwein, Rind (Kuh), Pferd, Kaninchen, Meerschweinchen
WB
Wirt: Kaninchen
Polyclonal
unconjugated
Produktnummer ABIN2790082
Produktdetails anti-DEF6 Antikörper
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Target
Alle DEF6 Antikörper anzeigen
DEF6
(Differentially Expressed in FDCP 6 Homolog (DEF6))
Bindungsspezifität
Alle Epitope für DEF6 Antikörper
C-Term
Reaktivität
Alle Reaktivitäten für DEF6 Antikörper
Human, Maus, Ratte, Hund, Schwein, Rind (Kuh), Pferd, Kaninchen, Meerschweinchen
Wirt
Alle Wirte für DEF6 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für DEF6 Antikörper
Polyklonal
Konjugat
Alle Konjugate für DEF6 Antikörper
Dieser DEF6 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für DEF6 Antikörper
Western Blotting (WB)
Sequenz
QERYIERAQQ EKEELQQEMA QQSRSLQQAQ QQLEEVRQNR QRADEDVEAA
Homologie
Cow: 93%, Dog: 93%, Guinea Pig: 83%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 90%, Rabbit: 93%, Rat: 93%
Produktmerkmale
This is a rabbit polyclonal antibody against DEF6. It was validated on Western Blot.
Aufreinigung
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the C-terminal region of human BRCC3
Top Product
Discover our top product DEF6 Primärantikörper
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Anwendungsinformationen
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Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Konzentration
1 mg/mL
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeat freeze-thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Details zu DEF6
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Target
DEF6
(Differentially Expressed in FDCP 6 Homolog (DEF6))
Andere Bezeichnung
DEF6 (DEF6 Produkte )
Synonyme
DEF6 antikoerper, Def6 antikoerper, zgc:63721 antikoerper, ibp antikoerper, slat antikoerper, swap70l antikoerper, MGC68775 antikoerper, 2410003F05Rik antikoerper, 6430538D02Rik antikoerper, AV094905 antikoerper, Ibp antikoerper, Slat antikoerper, Slat2 antikoerper, Slat6 antikoerper, IBP antikoerper, SLAT antikoerper, SWAP70L antikoerper, DEF6, guanine nucleotide exchange factor antikoerper, differentially expressed in FDCP 6a homolog (mouse) antikoerper, DEF6, guanine nucleotide exchange factor L homeolog antikoerper, differentially expressed in FDCP 6 antikoerper, DEF6 guanine nucleotide exchange factor antikoerper, DEF6 antikoerper, def6a antikoerper, def6.L antikoerper, def6 antikoerper, Def6 antikoerper
Hintergrund
This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. Alias Symbols: C6.1A, BRCC36, CXorf53 Protein Size: 376
Molekulargewicht
41 kDa
Gen-ID
79184
NCBI Accession
NM_001018055 , NP_001018065
UniProt
P46736
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