MACROD1 Antikörper (N-Term)
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- Target Alle MACROD1 Produkte
- MACROD1 (MACRO Domain Containing 1 (MACROD1))
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Bindungsspezifität
- N-Term
- Reaktivität
- Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser MACROD1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- MAAKVDLSTS TDWKEAKSFL KGLSDKQREE HYFCKDFVRL KKIPTWKEMA
- Homologie
- Cow: 100%, Dog: 92%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against MACROD1. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N-terminal region of Human MACROD1
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 325 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- MACROD1 (MACRO Domain Containing 1 (MACROD1))
- Andere Bezeichnung
- MACROD1 (MACROD1 Produkte)
- Synonyme
- lrp16 antikoerper, d930010j01rik antikoerper, LRP16 antikoerper, AI604841 antikoerper, AW743046 antikoerper, D930010J01Rik antikoerper, Lrp16 antikoerper, MACRO domain containing 1 antikoerper, MACRO domain containing 1 L homeolog antikoerper, MACROD1 antikoerper, macrod1 antikoerper, macrod1.L antikoerper, Macrod1 antikoerper
- Hintergrund
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MACROD1 deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. It plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen and may play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. It could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction and could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. MACROD1 enhances ESR1-mediated transcription activity.
Alias Symbols: LRP16
Protein Interaction Partner: BAG3, EPB41,
Protein Size: 325 - Molekulargewicht
- 36 kDa
- Gen-ID
- 28992
- NCBI Accession
- NM_014067, NP_054786
- UniProt
- Q9BQ69
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