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MACROD1 Antikörper (N-Term)

MACROD1 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2791083
  • Target Alle MACROD1 Produkte
    MACROD1 (MACRO Domain Containing 1 (MACROD1))
    Bindungsspezifität
    • 5
    • 1
    N-Term
    Reaktivität
    Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd
    Wirt
    • 6
    Kaninchen
    Klonalität
    • 6
    Polyklonal
    Konjugat
    • 2
    • 2
    • 1
    • 1
    Dieser MACROD1 Antikörper ist unkonjugiert
    Applikation
    • 4
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    MAAKVDLSTS TDWKEAKSFL KGLSDKQREE HYFCKDFVRL KKIPTWKEMA
    Homologie
    Cow: 100%, Dog: 92%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against MACROD1. It was validated on Western Blot.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N-terminal region of Human MACROD1
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 325 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    MACROD1 (MACRO Domain Containing 1 (MACROD1))
    Andere Bezeichnung
    MACROD1 (MACROD1 Produkte)
    Synonyme
    lrp16 antikoerper, d930010j01rik antikoerper, LRP16 antikoerper, AI604841 antikoerper, AW743046 antikoerper, D930010J01Rik antikoerper, Lrp16 antikoerper, MACRO domain containing 1 antikoerper, MACRO domain containing 1 L homeolog antikoerper, MACROD1 antikoerper, macrod1 antikoerper, macrod1.L antikoerper, Macrod1 antikoerper
    Hintergrund
    MACROD1 deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. It plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen and may play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. It could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction and could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. MACROD1 enhances ESR1-mediated transcription activity.
    Alias Symbols: LRP16
    Protein Interaction Partner: BAG3, EPB41,
    Protein Size: 325
    Molekulargewicht
    36 kDa
    Gen-ID
    28992
    NCBI Accession
    NM_014067, NP_054786
    UniProt
    Q9BQ69
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