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Oncogene Protein p190/bcr-Abl (N-Term) Antikörper
Reaktivität: Human, Rind (Kuh), Hund, Meerschweinchen, Pferd, Maus, Kaninchen, Ratte, Zebrafisch (Danio rerio)
WB
Wirt: Kaninchen
Polyclonal
unconjugated
Produktnummer ABIN2792051
Produktdetails
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Target
Oncogene Protein p190/bcr-Abl
Bindungsspezifität
N-Term
Reaktivität
Human, Rind (Kuh), Hund, Meerschweinchen, Pferd, Maus, Kaninchen, Ratte, Zebrafisch (Danio rerio)
Wirt
Alle Wirte für Oncogene Protein p190/bcr-Abl Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für Oncogene Protein p190/bcr-Abl Antikörper
Polyklonal
Konjugat
Alle Konjugate für Oncogene Protein p190/bcr-Abl Antikörper
Unkonjugiert
Applikation
Western Blotting (WB)
Sequenz
EDFSSGQSSR VSPSPTTYRM FRDKSRSPSQ NSQQSFDSSS PPTPQCHKRH
Homologie
Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 86%
Produktmerkmale
This is a rabbit polyclonal antibody against BCR-ABL1. It was validated on Western Blot.
Aufreinigung
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the N-terminal region of human BCR
Alternativen
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Anwendungsinformationen
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Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Konzentration
1 mg/mL
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeat freeze-thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Antigendetails
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Target
Oncogene Protein p190/bcr-Abl
Synonyme
ABL antikoerper, JTK7 antikoerper, bcr/abl antikoerper, c-ABL antikoerper, p150 antikoerper, v-abl antikoerper, ABL proto-oncogene 1, non-receptor tyrosine kinase antikoerper, ABL1 antikoerper
Hintergrund
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. Alias Symbols: ALL, CML, PHL, BCR1, D22S11, D22S662 Protein Size: 313
Molekulargewicht
34 kDa
Gen-ID
613
NCBI Accession
NM_004327 , NP_004318
UniProt
P11274
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