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FADD Antikörper (C-Term)

FADD Reaktivität: Human WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2792110
  • Target Alle FADD Antikörper anzeigen
    FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
    Bindungsspezifität
    • 17
    • 15
    • 14
    • 8
    • 8
    • 7
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 92
    • 61
    • 23
    • 19
    • 15
    Human
    Wirt
    • 96
    • 19
    Kaninchen
    Klonalität
    • 94
    • 21
    Polyklonal
    Konjugat
    • 61
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FADD Antikörper ist unkonjugiert
    Applikation
    • 84
    • 48
    • 29
    • 15
    • 15
    • 11
    • 11
    • 5
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequenz
    AHLVGALRSC QMNLVADLVQ EVQQARDLQN RSGAMSPMSW NSDASTSEAS
    Homologie
    Human: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against FADD. It was validated on Western Blot and immunohistochemistry.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human FADD
    Top Product
    Discover our top product FADD Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 208 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Thomas, Henson, Reed, Salsbury, Thorburn: "Direct binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD." in: The Journal of biological chemistry, Vol. 279, Issue 31, pp. 32780-5, (2004) (PubMed).

  • Target
    FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
    Andere Bezeichnung
    FADD (FADD Produkte)
    Synonyme
    MORT1 antikoerper, Mort1/FADD antikoerper, Mort1 antikoerper, TNFRSF6 antikoerper, adaptor antikoerper, fadd antikoerper, mort1 antikoerper, xfadd antikoerper, Fas associated via death domain antikoerper, Fas (TNFRSF6)-associated via death domain antikoerper, Fas associated via death domain S homeolog antikoerper, Fas (tnfrsf6)-associated via death domain antikoerper, FADD antikoerper, Fadd antikoerper, fadd.S antikoerper, fadd antikoerper
    Hintergrund
    The protein encoded by FADD is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade.
    Alias Symbols: GIG3, MORT1
    Protein Interaction Partner: CFLAR, CASP10, CASP8, ATG5, ATG12, TNF, TRADD, UBC, RIPK1, FAS, TNFSF10, SPOP, TNFRSF1A, MYD88, TNFRSF10A, TNFRSF10B, MKRN1, RIPK3, CUL3, TRAF2, PARK7, FASLG, LRRK2, IKBKG, BMX, FAF1, EDAR, DAPK1, CLIP3, DAXX, TNFAIP3, MAVS, KHDRBS1, TAB1, EZR, TRIM21, IR
    Protein Size: 208
    Molekulargewicht
    23 kDa
    Gen-ID
    8772
    NCBI Accession
    NM_003824, NP_003815
    UniProt
    Q13158
    Pathways
    Apoptose, TLR Signalweg, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
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