FLIP Antikörper (Middle Region)

Produktnummer ABIN504572

Produktdetails anti-FLIP Antikörper

Target: FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FLIP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LNPEGGKSGK APRRRAASMD SSSKLLRGRS KAPKKKPSVL PAPPEGATPT

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CFLAR. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CFLAR

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 480 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu FLIP

Target: FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))

Andere Bezeichnung: CFLAR (CFLAR Produkte)

Hintergrund: CFLAR belongs to the peptidase C14A family. It is a apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. The protein acts as an inhibitor of TNFRSF6 mediated apoptosis. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. CFLAR lacks enzymatic (caspase) activity.
Alias Symbols: CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLIP, I-FLICE, MRIT, USURPIN, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, FLAME1
Protein Interaction Partner: FADD, TRAF1, GSN, SPATS1, TNFSF10, RIPK1, RAF1, SMAD3, CASP8, HSP90AA1, STUB1, TNFRSF10A, TNFRSF10B, UBC, FASLG, ITCH, DAXX, CBLB, ATG3, XRCC6, Mib1, TP53, DEDD2, DEDD, RIPK2, IKBKB, MAP2K7, TRAF2, CASP10, CASP7, CASP6, MAP2K4, PSEN2, CASP2, CASP3, BCL2L1
Protein Size: 480

Molekulargewicht: 55 kDa

Gen-ID: 8837

NCBI Accession: NM_003879, NP_003870

UniProt: O15519

Pathways: Apoptose, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development