BIRC7 Antikörper (Middle Region)

Produktnummer ABIN2792130

Produktdetails anti-BIRC7 Antikörper

Target: BIRC7 (Baculoviral IAP Repeat-Containing 7 (BIRC7))

Bindungsspezifität: Middle Region

Reaktivität: Human, Rind (Kuh), Hund, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BIRC7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: EERTCKVCLD RAVSIVFVPC GHLVCAECAP GLQLCPICRA PVRSRVRTFL

Homologie: Cow: 85%, Dog: 84%, Human: 100%, Rabbit: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against BIRC7. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human BIRC7

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 298 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu BIRC7

Target: BIRC7 (Baculoviral IAP Repeat-Containing 7 (BIRC7))

Andere Bezeichnung: BIRC7 (BIRC7 Produkte)

Hintergrund: BIRC7 protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis.The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.
Alias Symbols: KIAP, LIVIN, ML-IAP, MLIAP, RNF50
Protein Interaction Partner: FAM124B, DIABLO, POLR1C, UBE2D2, PHF1, DDX6, CASP9, BIRC2, AES, CASP3, RAF1, XIAP, TAB1, HTRA2, UBC, BIRC7, UBE2I, UBE2E1, UBE2D3, UBE2D1, UBE2K, CASP7, XAF1,
Protein Size: 298

Molekulargewicht: 33 kDa

Gen-ID: 79444

NCBI Accession: NM_139317, NP_647478

UniProt: Q96CA5