YWHAE Antikörper (Middle Region)

Produktnummer ABIN2792142

Produktdetails anti-YWHAE Antikörper

Target: YWHAE (14-3-3 epsilon (YWHAE))

Bindungsspezifität: Middle Region

Reaktivität: Maus, Zebrafisch (Danio rerio), Meerschweinchen, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser YWHAE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: ELDTLSEESY KDSTLIMQLL RDNLTLWTSD MQGDGEEQNK EALQDVEDEN

Homologie: Dog: 100%, Guinea Pig: 100%, Mouse: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against YWHAE. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human YWHAE

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 255 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-YWHAE Antikörper (ABIN2792142)

Tak, Jang, Kim, Park, Suk, Yoon, Ahn, Lee, Joe: "14-3-3epsilon inhibits MK5-mediated cell migration by disrupting F-actin polymerization." in: Cellular signalling, Vol. 19, Issue 11, pp. 2379-87, (2007) (PubMed).

Details zu YWHAE

Target: YWHAE (14-3-3 epsilon (YWHAE))

Andere Bezeichnung: YWHAE (YWHAE Produkte)

Hintergrund: YWHAE is an adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. YWHAE binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. The binding generally results in the modulation of the activity of the binding partner.This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100 % identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: 14-3-3E, FLJ45465, KCIP-1, MDCR, MDS
Protein Interaction Partner: DTL, HUWE1, FAM53C, FBXW11, SORBS2, UBC, ABL1, GRB10, SIK2, CEP57, SIK3, TP53, IRS4, CBL, TUBB2A, TWF2, PROSC, FERMT2, PDIA4, RAP1GDS1, PTMA, PPP1R2, PDHB, PAK2, PAFAH1B2, YWHAH, XPO1, VCL, GSS, G6PD, EIF5, TBCB, CAPNS1, CAPN2, ALDH7A1, ATIC, ASNS, SCPEP1
Protein Size: 255

Molekulargewicht: 29 kDa

Gen-ID: 7531

NCBI Accession: NM_006761, NP_006752

UniProt: P62258

Pathways: Neurotrophin Signalübertragung, Myometrial Relaxation and Contraction, M Phase