CDK6 Antikörper (C-Term)

Produktnummer ABIN184161

Produktdetails anti-CDK6 Antikörper

Target: CDK6 (Cyclin-Dependent Kinase 6 (CDK6))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Rind (Kuh), Hund, Pferd, Kaninchen, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDK6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LLKCLTFNPA KRISAYSALS HPYFQDLERC KENLDSHLPP SQNTSELNTA

Homologie: Cow: 84%, Dog: 84%, Horse: 84%, Human: 100%, Mouse: 76%, Pig: 84%, Rabbit: 84%

Produktmerkmale: This is a rabbit polyclonal antibody against CDK6. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CDK6

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 326 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CDK6

Target: CDK6 (Cyclin-Dependent Kinase 6 (CDK6))

Andere Bezeichnung: CDK6 (CDK6 Produkte)

Hintergrund: CDK6 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.
Alias Symbols: MGC59692, PLSTIRE
Protein Interaction Partner: PSMA3, DAB1, CDKN2D, CDKN2C, CDKN2B, CCND3, UBC, CCND2, AMY2A, CDKN2A, CDK6, PIGR, DMBT1, WDR33, CDKL3, RB1, CDK4, UCHL1, PML, NUMA1, NFATC3, MYC, MLLT3, MEF2D, MCM2, ISL1, HSP90AA1, HSF1, FOXO3, FOXM1, EZH2, ELK1, DDIT3, ATF6B, CDKN1A, CDC6, CCND1, ZSCAN
Protein Size: 326

Molekulargewicht: 37 kDa

Gen-ID: 1021

NCBI Accession: NM_001259, NP_001250

UniProt: Q00534

Pathways: Zellzyklus, Mitotic G1-G1/S Phases