FFAR1 Antikörper (N-Term)

Produktnummer ABIN2792205

Produktdetails anti-FFAR1 Antikörper

Target: FFAR1 (Free Fatty Acid Receptor 1 (FFAR1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Schwein, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FFAR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: KVSEAALSLL VLILIITSAS RSQPKVPEWV NTPSTCCLKY YEKVLPRRLV

Homologie: Cow: 100%, Dog: 100%, Human: 100%, Mouse: 85%, Pig: 92%, Rat: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against FFAR1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FFAR1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 300 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-FFAR1 Antikörper (ABIN2792205)

Sum, Tikhonova, Neumann, Engel, Raaka, Costanzi, Gershengorn: "Identification of residues important for agonist recognition and activation in GPR40." in: The Journal of biological chemistry, Vol. 282, Issue 40, pp. 29248-55, (2007) (PubMed).

Details zu FFAR1

Target: FFAR1 (Free Fatty Acid Receptor 1 (FFAR1))

Andere Bezeichnung: FFAR1 (FFAR1 Produkte)

Hintergrund: FFAR1 is receptor for medium and long chain saturated and unsaturated fatty acids. It binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G-proteins that activate phospholipase C.
Alias Symbols: FFA1R, GPCR40, GPR40
Protein Interaction Partner: GNAQ, GNAI1,
Protein Size: 300

Molekulargewicht: 31 kDa

Gen-ID: 2864

NCBI Accession: NM_005303, NP_005294

UniProt: O14842

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Peptide Hormone Metabolism, Carbohydrate Homeostasis