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PRDM1 Antikörper (Middle Region)

PRDM1 Reaktivität: Human, Maus, Ratte, Hund, Schwein, Rind (Kuh), Kaninchen, Pferd, Meerschweinchen WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2792524
  • Target Alle PRDM1 Antikörper anzeigen
    PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))
    Bindungsspezifität
    • 8
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    • 63
    • 17
    • 11
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Hund, Schwein, Rind (Kuh), Kaninchen, Pferd, Meerschweinchen
    Wirt
    • 40
    • 23
    • 3
    • 2
    Kaninchen
    Klonalität
    • 45
    • 23
    Polyklonal
    Konjugat
    • 46
    • 7
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PRDM1 Antikörper ist unkonjugiert
    Applikation
    • 52
    • 36
    • 13
    • 11
    • 6
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequenz
    VEDDISVISV VEKEILAVVR KEKEETGLKV SLQRNMGNGL LSSGCSLYES
    Kreuzreaktivität
    Rind (Kuh), Human, Maus, Ratte (Rattus)
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 84%, Horse: 100%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 92%, Rat: 92%
    Produktmerkmale
    This is a rabbit polyclonal antibody against PRDM1. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human PRDM1
    Top Product
    Discover our top product PRDM1 Primärantikörper
  • Applikationshinweise
    WB Suggested Anti-PRDM1 Antibody Titration: 0.2-1 µg/mL
    ELISA Titer: 1:62500
    Positive Control: SH-SYSY cell lysate.
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 691 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Arulanandam, Batenchuk, Angarita, Ottolino-Perry, Cousineau, Mottashed, Burgess, Falls, De Silva, Tsang, Howe, Bourgeois-Daigneault, Conrad, Daneshmand, Breitbach, Kirn, Raptis, Sad, Atkins, Huh et al.: "VEGF-Mediated Induction of PRD1-BF1/Blimp1 Expression Sensitizes Tumor Vasculature to Oncolytic Virus Infection. ..." in: Cancer cell, Vol. 28, Issue 2, pp. 210-24, (2015) (PubMed).

  • Target
    PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))
    Andere Bezeichnung
    PRDM1 / BLIMP1 (PRDM1 Produkte)
    Synonyme
    GB11750 antikoerper, CG5249 antikoerper, Dmel\\CG5249 antikoerper, blimp-1 antikoerper, dBlimp-1 antikoerper, dBlimp1 antikoerper, Blimp-1 antikoerper, Blimp1 antikoerper, nrd antikoerper, prdm1 antikoerper, ubo antikoerper, wu:fb99c12 antikoerper, zgc:91885 antikoerper, MGC52536 antikoerper, PRDM1 antikoerper, blimp1 antikoerper, xblimp1 antikoerper, prdi-bf1 antikoerper, BLIMP1 antikoerper, PRDI-BF1 antikoerper, ZNFPR1A1 antikoerper, PR/SET domain 1 antikoerper, probable serine/threonine-protein kinase DDB_G0282963 antikoerper, CG5249 gene product from transcript CG5249-RF antikoerper, blimp-1 antikoerper, PR domain containing 1a, with ZNF domain antikoerper, PR domain 1 S homeolog antikoerper, B lymphocyte induced maturation protein 1 antikoerper, PR domain 1 antikoerper, PR domain containing 1, with ZNF domain antikoerper, PRDM1 antikoerper, LOC408295 antikoerper, Blimp-1 antikoerper, CpipJ_CPIJ007425 antikoerper, prdm1a antikoerper, prdm1.S antikoerper, prdm1 antikoerper, Prdm1 antikoerper
    Hintergrund
    PRDM1 is a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.
    Alias Symbols: BLIMP1, MGC118922, MGC118923, MGC118924, MGC118925, PRDI-BF1
    Protein Interaction Partner: PRMT5, SENP1, EHMT2, PIAS1, SUMO1, IRF2, IRF1, HDAC2, HDAC1, HIST1H1A, MS4A1, HSP90AA1, ATXN1, ELAVL1, KDM1A, IRF4, TLE2, TLE1, AES, PRMT7, HIST2H3A,
    Protein Size: 691
    Molekulargewicht
    77 kDa
    Gen-ID
    639
    NCBI Accession
    NM_182907, NP_878911
    UniProt
    Q86WM7
    Pathways
    Regulation of Muscle Cell Differentiation
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