NFKBIL2 Antikörper (Middle Region)

Produktnummer ABIN2792627

Produktdetails anti-NFKBIL2 Antikörper

Target: NFKBIL2 (Tonsoku-Like, DNA Repair Protein (NFKBIL2))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NFKBIL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: RAIIHVSLAT TLGDMKDHHG AVRHYEEELR LRSGNVLEEA KTWLNIALSR

Kreuzreaktivität: Hund, Human, Maus, Ratte (Rattus)

Homologie: Dog: 84%, Human: 100%, Mouse: 83%, Rat: 83%

Produktmerkmale: This is a rabbit polyclonal antibody against NFKBIL2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NFKBIL2

Anwendungsinformationen

Applikationshinweise: WB Suggested Anti-NFKBIL2 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:62500
Positive Control: 293T cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1219 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-NFKBIL2 Antikörper (ABIN2792627)

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

Details zu NFKBIL2

Target: NFKBIL2 (Tonsoku-Like, DNA Repair Protein (NFKBIL2))

Andere Bezeichnung: NFKBIL2 / IKBR (NFKBIL2 Produkte)

Synonyme: IKBR antikoerper, NFKBIL2 antikoerper, 2810439M11Rik antikoerper, Nfkbil2 antikoerper, im:7145273 antikoerper, nfkbil2 antikoerper, tonsl antikoerper, tonsoku like, DNA repair protein antikoerper, tonsoku-like, DNA repair protein antikoerper, TONSL antikoerper, Tonsl antikoerper, tonsl antikoerper

Hintergrund: NFKBIL2 is thought to be a negative regulator of NF-kappa-B mediated transcription. It may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus.The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus.
Alias Symbols: FLJ40087, IKBR, NFKBIL2
Protein Interaction Partner: HIST3H3, MCM6, MCM2, MMS22L, ASF1B, ASF1A, UBC, MYC, MAU2, SLC25A5, SUPT16H, SUGT1, AIFM1, HIST1H2BL, XRCC5, SSRP1, SLC25A3, TONSL, MCM4, HIST1H2AE, HIST1H1B, HIST1H1C, XRCC6, GSK3B, MCM7, MCM5, MCM3, EWSR1,
Protein Size: 1219

Molekulargewicht: 133 kDa

Gen-ID: 4796

NCBI Accession: NM_013432, NP_038460

UniProt: Q96HA7

Pathways: Maintenance of Protein Location