SUB1 Antikörper (Middle Region)

Produktnummer ABIN2792675

Produktdetails anti-SUB1 Antikörper

Target: SUB1 (Activated RNA Polymerase II Transcriptional Coactivator p15 (SUB1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Zebrafisch (Danio rerio), Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SUB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: NMFQIGKMRY VSVRDFKGKV LIDIREYWMD PEGEMKPGRK GISLNPEQWS

Kreuzreaktivität: Rind (Kuh), Hund, Huhn, Human, Maus, Ratte (Rattus)

Homologie: Cow: 100%, Dog: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Yeast: 91%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PC4. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PC4

Anwendungsinformationen

Applikationshinweise: WB Suggested Anti-PC4 Antibody Titration: 0.5-1.0 µg/mL
Positive Control: HepG2 cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 127 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SUB1

Target: SUB1 (Activated RNA Polymerase II Transcriptional Coactivator p15 (SUB1))

Andere Bezeichnung: SUB1 / PC4 (SUB1 Produkte)

Hintergrund: PC4 (activated RNA polymerase II transcription cofactor 4) is a transcriptional coactivator, possessing the ability to suppress promoter-driven as well as nonspecific transcription via its DNA binding activity. The repressive activity of PC4 on promoter-driven transcription is alleviated by transcription factor TFIIH. TFIIH protects promoters from PC4-mediated repression by relieving the topological constraint imposed by PC4 through the ERCC3 helicase activity.
Alias Symbols: P15, PC4, p14
Protein Interaction Partner: HUWE1, SUB1, UBC, rev, CLK4, CDK2, HNF4A, FN1, CSNK2A1, SMURF1, RPL18A, LAMP2, CDC5L, APP, YWHAZ, GTF3C1, ELAVL1, SUMO2, HDGF, Shoc2, Kif1c, POLR2B, POLR2A, CBX5, RCOR1, REST, BANF1, ADAP1, GTF2A1L, EP300, POU2AF1, CSTF2, TBP, TAF1, PCNA, HSF1, PSIP1, SP1
Protein Size: 127

Molekulargewicht: 14 kDa

Gen-ID: 10923

NCBI Accession: NM_006713, NP_006704

UniProt: P53999