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Nucleobindin 1 Antikörper (C-Term)

NUCB1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2792698
  • Target Alle Nucleobindin 1 (NUCB1) Antikörper anzeigen
    Nucleobindin 1 (NUCB1)
    Bindungsspezifität
    • 15
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 33
    • 19
    • 19
    • 2
    Human
    Wirt
    • 31
    • 6
    Kaninchen
    Klonalität
    • 33
    • 4
    Polyklonal
    Konjugat
    • 23
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Nucleobindin 1 Antikörper ist unkonjugiert
    Applikation
    • 35
    • 13
    • 13
    • 12
    • 8
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    Western Blotting (WB)
    Sequenz
    PAAHPEGQLK FHPDTDDVPV PAPAGDQKEV DTSEKKLLER LPEVEVPQHL
    Kreuzreaktivität
    Human
    Homologie
    Human: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against NUCB1. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human NUCB1
    Top Product
    Discover our top product NUCB1 Primärantikörper
  • Applikationshinweise
    WB Suggested Anti-NUCB1 Antibody Titration: 0.2-1 µg/mL
    ELISA Titer: 1:1562500
    Positive Control: HepG2 cell lysate.
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 461 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Bonito-Oliva, Barbash, Sakmar, Graham: "Nucleobindin 1 binds to multiple types of pre-fibrillar amyloid and inhibits fibrillization." in: Scientific reports, Vol. 7, pp. 42880, (2017) (PubMed).

    Larkin, Ribeiro, Lavoie: "Topology and membrane anchoring of the lysosomal storage disease-related protein CLN5." in: Human mutation, Vol. 34, Issue 12, pp. 1688-97, (2013) (PubMed).

    Lin, Fischer, Lavoie, Huang, Farquhar: "Calnuc plays a role in dynamic distribution of Galphai but not Gbeta subunits and modulates ACTH secretion in AtT-20 neuroendocrine secretory cells." in: Molecular neurodegeneration, Vol. 4, pp. 15, (2009) (PubMed).

    Valencia, Cotten, Duan, Liu: "Modulation of nucleobindin-1 and nucleobindin-2 by caspases." in: FEBS letters, Vol. 582, Issue 2, pp. 286-90, (2008) (PubMed).

    Sugeno, Takeda, Hasegawa, Kobayashi, Kikuchi, Mori, Wakabayashi, Itoyama: "Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death." in: The Journal of biological chemistry, Vol. 283, Issue 34, pp. 23179-88, (2008) (PubMed).

    Lin, Li, Zhang, Huang, Tong, Farquhar, Xu: "Calnuc binds to Alzheimer's beta-amyloid precursor protein and affects its biogenesis." in: Journal of neurochemistry, Vol. 100, Issue 6, pp. 1505-14, (2007) (PubMed).

  • Target
    Nucleobindin 1 (NUCB1)
    Andere Bezeichnung
    Nucleobindin-1 (NUCB1 Produkte)
    Synonyme
    nuc antikoerper, MGC69294 antikoerper, MGC81496 antikoerper, NUCB1 antikoerper, zgc:153192 antikoerper, DKFZp459O1814 antikoerper, B230337F23Rik antikoerper, C77483 antikoerper, Calnuc antikoerper, MTEST82 antikoerper, Nucb antikoerper, CALNUC antikoerper, NUC antikoerper, nucleobindin 1 antikoerper, nucleobindin 1 S homeolog antikoerper, nucb1 antikoerper, nucb1.S antikoerper, NUCB1 antikoerper, Nucb1 antikoerper
    Hintergrund
    Nucleobindin, also known as calnuc, participates in Ca2+ storage in the Golgi, as well as in other biological processes that involve DNA-binding and protein-protein interactions.
    Alias Symbols: NUC, CALNUC
    Protein Interaction Partner: REL, UBC, MDM2, CTPS2, RAD23B, PRKDC, METTL1, GTF2I, CBS, XPNPEP1, WARS, PTGS2, XPO1, SET, RBL1, MYC, HIVEP1, GNAS, GNAI3, GNAI1, KLC4, PTGS1, NDN, GNAI2, GNAO1, GNAZ,
    Protein Size: 461
    Molekulargewicht
    54 kDa
    Gen-ID
    4924
    NCBI Accession
    NM_006184, NP_006175
    UniProt
    Q02818
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