NFkB Antikörper (C-Term)

Produktnummer ABIN2795621

Produktdetails anti-NFkB Antikörper

Target: NFkB (Nuclear Factor kappa B (NFkB))

Bindungsspezifität: AA 911-937, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NFkB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit Anti-Human NFKB(p105) (C-term S933) Antibody

Immunogen: This NFKB(p105) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 911-937 amino acids from the C-terminal region of human NFKB(p105).

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Western Blot
Recommended Dilutions
WB: 1:1000NFKB(p105) Antibody (C-term S933) .

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.500 mg/mL

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C (short-term), -20°C (long-term)

Details zu NFkB

Target: NFkB (Nuclear Factor kappa B (NFkB))

Andere Bezeichnung: NFKB (NFkB Produkte)

Hintergrund:

Target Description: This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.

Gene Symbol: NFKB1

Molekulargewicht: 105356 Da

Gen-ID: 4790

UniProt: P19838

Pathways: Ubiquitin Proteasome Pathway, S100 Proteine