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MTMR14 Antikörper (AA 161-260) (AbBy Fluor® 594)

MTMR14 Reaktivität: Maus WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 594
Produktnummer ABIN2804353
  • Target Alle MTMR14 Antikörper anzeigen
    MTMR14 (Myotubularin Related Protein 14 (MTMR14))
    Bindungsspezifität
    • 14
    • 8
    • 7
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 161-260
    Reaktivität
    • 31
    • 19
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Maus
    Wirt
    • 39
    • 7
    Kaninchen
    Klonalität
    • 41
    • 5
    Polyklonal
    Konjugat
    • 23
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MTMR14 Antikörper ist konjugiert mit AbBy Fluor® 594
    Applikation
    • 43
    • 22
    • 12
    • 12
    • 7
    • 5
    • 5
    • 4
    • 3
    • 2
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Maus
    Homologie
    Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human MTMR14
    Isotyp
    IgG
    Top Product
    Discover our top product MTMR14 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    MTMR14 (Myotubularin Related Protein 14 (MTMR14))
    Andere Bezeichnung
    MTMR14 (MTMR14 Produkte)
    Synonyme
    fc14d11 antikoerper, wu:fc14d11 antikoerper, MGC131146 antikoerper, C3orf29 antikoerper, 1110061O04Rik antikoerper, AW553738 antikoerper, C76151 antikoerper, RGD1304842 antikoerper, jumpy antikoerper, myotubularin related protein 14 antikoerper, myotubularin-related protein 14 antikoerper, myotubularin related protein 14 S homeolog antikoerper, mtmr14 antikoerper, LOC703936 antikoerper, mtmr14.S antikoerper, MTMR14 antikoerper, Mtmr14 antikoerper
    Hintergrund

    Synonyms: C3orf29, Egg derived tyrosine phosphatase homolog, FLJ11546, FLJ22405, FLJ46453, FLJ90311, HCV NS5A transactivated protein 4 splice variant A binding protein 1, HCV NS5A-transactivated protein 4 splice variant A-binding protein 1, hJumpy, jumpy, MTMR 14, MTMR14, MTMR-14, MTMRE_HUMAN, Myotubularin related protein 14, Myotubularin-related protein 14, NS5ATP4ABP1.

    Background: Myotubularin-related protein 14 (MTMR14), also known as Jumpy, is a myotubularin-related phosphoinositol-3-phosphate (PI3P) phosphatase (1). Mutations in the MTMR14 gene have been associated with centronuclear myopathy (1). MTMR14 deficiency in mice leads to altered calcium homeostasis and muscle disorders (2). MTMR14 has also been shown to play a role in autophagy, a process that is highly regulated by phosphatidylinositides through the type III PI3K, Vps34 (3). MTMR14 was localized to autophagic isolation membranes and early autophagosomes (3). In these studies, MTMR14 inhibited autophagy and mutations of MTMR14 associated with centronuclear myopathy were also defective in autophagy inhibition. In zebrafish, MTMR14 knockdown was shown to increase the number of autophagosomes, suggesting that its activity is associated with an inhibition of autophagy (4).

    Pathways
    Inositol Metabolic Process
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