NEDD4 Antikörper (AA 801-900) (AbBy Fluor® 594)
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- Target Alle NEDD4 Antikörper anzeigen
- NEDD4 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4))
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Bindungsspezifität
- AA 801-900
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Reaktivität
- Human, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser NEDD4 Antikörper ist konjugiert mit AbBy Fluor® 594
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Applikation
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Human, Ratte
- Homologie
- Mouse,Dog,Cow,Pig,Horse,Chicken,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human NEDD4
- Isotyp
- IgG
- Top Product
- Discover our top product NEDD4 Primärantikörper
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- Applikationshinweise
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- NEDD4 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4))
- Andere Bezeichnung
- NEDD4 (NEDD4 Produkte)
- Synonyme
- NEDD4-1 antikoerper, RPF1 antikoerper, AA959633 antikoerper, AL023035 antikoerper, AU019897 antikoerper, E430025J12Rik antikoerper, Nedd4-1 antikoerper, Nedd4a antikoerper, mKIAA0093 antikoerper, CG32184 antikoerper, CG42279 antikoerper, CG7555 antikoerper, DNedd4 antikoerper, Dmel\\CG42279 antikoerper, Dmel_CG32184 antikoerper, Dmel_CG7555 antikoerper, dNedd4 antikoerper, dNedd4-1 antikoerper, nedd4 antikoerper, GB16853 antikoerper, NEDD4 antikoerper, Nedd4 antikoerper, neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase antikoerper, neural precursor cell expressed, developmentally down-regulated 4 antikoerper, CG42279 gene product from transcript CG42279-RJ antikoerper, E3 ubiquitin-protein ligase Nedd-4 antikoerper, E3 ubiquitin-protein ligase NEDD4 antikoerper, NEDD4 antikoerper, Nedd4 antikoerper, LOC411723 antikoerper, LOC100457150 antikoerper, nedd4 antikoerper, LOC100547485 antikoerper
- Hintergrund
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Synonyms: RPF1, NEDD4-1, E3 ubiquitin-protein ligase NEDD4, Cell proliferation-inducing gene 53 protein, Neural precursor cell expressed developmentally down-regulated protein 4, NEDD-4, NEDD4, KIAA0093, PIG53
Background: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role in facilitating viral budding.
- Gen-ID
- 4734
- UniProt
- P46934
- Pathways
- Notch Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Skeletal Muscle Fiber Development, Signaling Events mediated by VEGFR1 and VEGFR2
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