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CYTIP Antikörper (AA 1-100) (AbBy Fluor® 594)

CYTIP Reaktivität: Human WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 594
Produktnummer ABIN2805652
  • Target Alle CYTIP Antikörper anzeigen
    CYTIP (Cytohesin 1 Interacting Protein (CYTIP))
    Bindungsspezifität
    • 14
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 1-100
    Reaktivität
    • 22
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 22
    • 1
    Kaninchen
    Klonalität
    • 23
    Polyklonal
    Konjugat
    • 10
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CYTIP Antikörper ist konjugiert mit AbBy Fluor® 594
    Applikation
    • 22
    • 12
    • 12
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Horse,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human PSCDBP/CYTIP
    Isotyp
    IgG
    Top Product
    Discover our top product CYTIP Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    CYTIP (Cytohesin 1 Interacting Protein (CYTIP))
    Andere Bezeichnung
    PSCDBP/CYTIP (CYTIP Produkte)
    Synonyme
    B3-1 antikoerper, CASP antikoerper, CYBR antikoerper, CYTHIP antikoerper, HE antikoerper, PSCDBP antikoerper, A130053M09Rik antikoerper, AI462064 antikoerper, C80816 antikoerper, Cbp antikoerper, Cybr antikoerper, Pscdbp antikoerper, cytohesin 1 interacting protein antikoerper, CYTIP antikoerper, Cytip antikoerper, cytip antikoerper
    Hintergrund

    Synonyms: B31, CASP, Cbp HE, CYBR, CYTHIP, Cytip, CYTIP_HUMAN, Cytohesin binder and regulator, Cytohesin-associated scaffolding protein, Cytohesin-binding protein HE, Cytohesin-interacting protein, HE antibody Pleckstrin Homology Sec7 and Coiled-Coil Domains Binding Protein, Pleckstrin homology Sec7 and coiled-coil domains-binding protein.

    Background: CYTIP is a cytoplasmic protein that is involved in lymphocytic cell adhesion. Expressed primarily in hematopoetic cells, CYTIP regulates the activity of cytohesin-1 (an integrin-activating protein involved in cell adhesion) by mediating its recruitment to the leukocyte membrane. Through its ability to bind cytohesin-1, CYTIP is able to sequester it to the cytoplasm, thereby preventing cytohesin-1 translocation to lymphocytes and interrupting the flow of information in the cell adhesion pathway. CYTIP can be recruited from the cytoplasm to the membrane by leukocyte integrins which interact with CYTIP through its PDZ domain. After membrane translocation, CYTIP can be re-located to the cytoplasm via exposure to a phorbol ester. Additionally, CYTIP associates with SNX27 (sorting nexin 27) and helps to coordinate trafficking and signaling complexes. Up-regulation of CYTIP is observed in maturing dendritic cells, suggesting a possible role in developmentally-controlled cell adhesion.

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