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EYA1 Antikörper (AA 231-330) (AbBy Fluor® 647)

EYA1 Reaktivität: Human IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 647
Produktnummer ABIN2807748
  • Target Alle EYA1 Antikörper anzeigen
    EYA1 (Eyes Absent Homolog 1 (EYA1))
    Bindungsspezifität
    • 15
    • 14
    • 10
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 231-330
    Reaktivität
    • 34
    • 24
    • 8
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    Human
    Wirt
    • 44
    • 1
    • 1
    Kaninchen
    Klonalität
    • 46
    Polyklonal
    Konjugat
    • 19
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser EYA1 Antikörper ist konjugiert mit AbBy Fluor® 647
    Applikation
    • 27
    • 23
    • 12
    • 12
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Human
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human EYA1
    Isotyp
    IgG
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  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    EYA1 (Eyes Absent Homolog 1 (EYA1))
    Andere Bezeichnung
    EYA1 (EYA1 Produkte)
    Synonyme
    EYA1 antikoerper, bop antikoerper, bor antikoerper, XEya1 antikoerper, wu:fc13c10 antikoerper, zgc:100770 antikoerper, BOP antikoerper, BOR antikoerper, BOS1 antikoerper, EYA transcriptional coactivator and phosphatase 1 antikoerper, EYA transcriptional coactivator and phosphatase 1 L homeolog antikoerper, EYA1 antikoerper, eya1 antikoerper, Eya1 antikoerper, eya1.L antikoerper
    Hintergrund

    Synonyms: BOP, BOR, BOS1, OFC1, Eyes absent homolog 1, EYA1

    Background: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears. Together with SIX1, it plays an important role in hypaxial muscle development, in this it is functionally redundant with EYA2.

    Gen-ID
    2138
    UniProt
    Q99502
    Pathways
    Sensory Perception of Sound, Positive Regulation of Response to DNA Damage Stimulus
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