GJA8 Antikörper (N-Term)

Produktnummer ABIN1882072

Produktdetails anti-GJA8 Antikörper

Target: GJA8 (Gap Junction Protein, alpha 8, 50kDa (GJA8))

Bindungsspezifität: AA 99-130, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GJA8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. Purified Rabbit Polyclonal Antibody (Pab)

Immunogen: This Connexin 50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 99-130 amino acids from the N-terminal region of human Connexin 50.

Klon: RB1381

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.79 mg/mL

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Referenzen für anti-GJA8 Antikörper (ABIN1882072)

Ponsaerts, De Vuyst, Retamal, Dhondt, Vermeire, Wang, De Smedt, Zimmermann, Himpens, Vereecke, Leybaert, Bultynck: "Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 11, pp. 4378-95, (2010) (PubMed).

Shiels, Mackay, Ionides, Berry, Moore, Bhattacharya: "A missense mutation in the human connexin50 gene (GJA8) underlies autosomal dominant "zonular pulverulent" cataract, on chromosome 1q." in: American journal of human genetics, Vol. 62, Issue 3, pp. 526-32, (1998) (PubMed).

Church, Wang, Steele: "The human lens intrinsic membrane protein MP70 (Cx50) gene: clonal analysis and chromosome mapping." in: Current eye research, Vol. 14, Issue 10, pp. 979-81, (1996) (PubMed).

Church, Wang, Steele: "The human lens intrinsic membrane protein MP70 (Cx50) gene: clonal analysis and chromosome mapping." in: Current eye research, Vol. 14, Issue 3, pp. 215-21, (1995) (PubMed).

Details zu GJA8

Target: GJA8 (Gap Junction Protein, alpha 8, 50kDa (GJA8))

Andere Bezeichnung: Connexin 50 (GJA8 Produkte)

Synonyme: Aey5 antikoerper, Cnx50 antikoerper, Cx50 antikoerper, Lop10 antikoerper, CAE antikoerper, CAE1 antikoerper, CTRCT1 antikoerper, CX50 antikoerper, CZP1 antikoerper, MP70 antikoerper, Cx45.6 antikoerper, gap junction protein, alpha 8 antikoerper, gap junction protein alpha 8 antikoerper, Gja8 antikoerper, GJA8 antikoerper

Hintergrund: GJA8 is a an integral membrane protein that belongs to the connexin family, alpha-type (group II) subfamily. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. This particular connexin only forms junctional channels. GJA8 is expressed in the eye lens, and defects in GJA8 are the cause of zonular pulverulent cataract type 1 (CZP1), a form of autosomal dominant congenital cataract.

Synonyms: GJA8, Gap junction alpha-8 protein, Connexin-50, Lens fiber protein MP70

NCBI Accession: NP_005258

UniProt: P48165