pADPR Antikörper
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- Target
- pADPR
- Reaktivität
- Alle Spezies
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Unkonjugiert
- Applikation
- Immunohistochemistry (IHC), ELISA, Western Blotting (WB), Immunoprecipitation (IP)
- Produktmerkmale
- Recognizes DNA-damage and apoptosis related poly-ADP ribosylated proteins and poly (ADP-ribose) polymer
- Aufreinigung
- Protein A affinity column
- Immunogen
- poly(ADP-ribose)
- Klon
- 10H
- Isotyp
- IgG3
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- Applikationshinweise
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WB 5 µg/mL,
IH 2 µg/mL - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS, pH 7.4, 1 % BSA, 0.05 % sodium ayide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid freeze/thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Stable for 1 year from date of shipment when stored at -20 °C or -70 °C. Stable for at least 1 month at 4 °C.
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Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains." in: Structure (London, England : 1993), Vol. 21, Issue 3, pp. 462-75, (2013) (PubMed).
: "CHFR protein regulates mitotic checkpoint by targeting PARP-1 protein for ubiquitination and degradation." in: The Journal of biological chemistry, Vol. 287, Issue 16, pp. 12975-84, (2012) (PubMed).
: "Poly (ADP-ribose) polymerase 1 is required for protein localization to Cajal body." in: PLoS genetics, Vol. 5, Issue 2, pp. e1000387, (2009) (PubMed).
: "Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes." in: Nucleic acids research, Vol. 36, Issue 22, pp. 6959-76, (2008) (PubMed).
: "Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function." in: Nature cell biology, Vol. 7, Issue 11, pp. 1133-9, (2005) (PubMed).
: "Attenuation of neointima formation through the inhibition of DNA repair enzyme PARP-1 in balloon-injured rat carotid artery." in: American journal of physiology. Heart and circulatory physiology, Vol. 287, Issue 2, pp. H659-66, (2004) (PubMed).
: "
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Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains." in: Structure (London, England : 1993), Vol. 21, Issue 3, pp. 462-75, (2013) (PubMed).
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- Target
- pADPR
- Hintergrund
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Synonyms: poly(ADP-ribose)
Poly(ADP-ribose) or pADPr is a polymer synthesized by a class of enzymes named poly(ADP-ribose) polymerase (PARP). Using NAD+ as substrate, PARP catalyzes the formation of the polymer pADPr, with chain lengths ranging from 2 to 300 residues, containing approximately 2 % branching in the chain. pADPr becomes attached to nuclear proteins, and to PARP itself (automodification).
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