PTBP1 Antikörper

Produktnummer ABIN2854334

Produktdetails anti-PTBP1 Antikörper

Target: PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus

Produktmerkmale: Rabbit Polyclonal antibody to hnRNP 1 (polypyrimidine tract-binding protein 1)
hnRNP 1 antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human PTBP1. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu PTBP1

Target: PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))

Andere Bezeichnung: polypyrimidine tract binding protein 1 (PTBP1 Produkte)

Synonyme: HNRNP-I antikoerper, HNRNPI antikoerper, HNRPI antikoerper, PTB antikoerper, PTB-1 antikoerper, PTB-T antikoerper, PTB2 antikoerper, PTB3 antikoerper, PTB4 antikoerper, pPTB antikoerper, Ptb antikoerper, hnrpi antikoerper, hnrnp-I antikoerper, vgrbp60 antikoerper, AA407203 antikoerper, AL033359 antikoerper, Pybp antikoerper, Pybp1 antikoerper, Pybp2 antikoerper, ptbp1 antikoerper, wu:fb99f12 antikoerper, zgc:110689 antikoerper, ptb antikoerper, ATPTB1 antikoerper, POLYPYRIMIDINE TRACT-BINDING antikoerper, POLYPYRIMIDINE TRACT-BINDING PROTEIN 1 antikoerper, T4P13.16 antikoerper, T4P13_16 antikoerper, polypyrimidine tract-binding protein 1 antikoerper, PTBP1 antikoerper, polypyrimidine tract binding protein 1 antikoerper, polypyrimidine tract binding protein 1 S homeolog antikoerper, polypyrimidine tract-binding protein antikoerper, polypyrimidine tract binding protein 1a antikoerper, polypyrimidine tract binding protein 1 L homeolog antikoerper, polypyrimidine tract-binding protein 1 antikoerper, PTBP1 antikoerper, ptbp1.S antikoerper, NAEGRDRAFT_80143 antikoerper, LOC100285404 antikoerper, Ptbp1 antikoerper, ptbp1a antikoerper, ptbp1.L antikoerper, PTB1 antikoerper, LOC100061673 antikoerper

Hintergrund: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

Cellular Localization: Nucleus

Molekulargewicht: 57 kDa

Gen-ID: 5725

UniProt: P26599

Pathways: Regulation of Muscle Cell Differentiation