UNG Antikörper

Produktnummer ABIN2854428

Produktdetails anti-UNG Antikörper

Target: UNG (Uracil-DNA Glycosylase (UNG))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UNG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Whole Mount) (IHC (wm))

Kreuzreaktivität: Human, Zebrafisch (Danio rerio)

Produktmerkmale: Rabbit Polyclonal antibody to UNG (uracil-DNA glycosylase)
UNG antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human UNG. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-UNG Antikörper (ABIN2854428)

Wu, Chen, Sun, Wu, Jia, Meng: "Uracil-DNA glycosylase is involved in DNA demethylation and required for embryonic development in the zebrafish embryo." in: The Journal of biological chemistry, Vol. 289, Issue 22, pp. 15463-73, (2014) (PubMed).

Details zu UNG

Target: UNG (Uracil-DNA Glycosylase (UNG))

Andere Bezeichnung: uracil DNA glycosylase (UNG Produkte)

Substanzklasse: Viral Protein

Hintergrund: This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2.

Cellular Localization: Isoform 1: Mitochondrion , Isoform 2: Nucleus

Molekulargewicht: 35 kDa

Gen-ID: 7374

UniProt: P13051

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response