KIR3DL1 Antikörper (Center)

Produktnummer ABIN2854554

Produktdetails anti-KIR3DL1 Antikörper

Target: KIR3DL1 (Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 1 (KIR3DL1))

Bindungsspezifität: Center

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIR3DL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktmerkmale: Rabbit polyclonal antibody to CD158e (killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1)
CD158e antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human CD158e. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Suggested dilution Reference Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceWestern blot1:500-1:3000*

Kommentare:

Positive Control: A431 , H1299 , HeLaS3 , HepG2 , Molt-4 , Raji

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu KIR3DL1

Target: KIR3DL1 (Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 1 (KIR3DL1))

Andere Bezeichnung: CD158e (KIR3DL1 Produkte)

Synonyme: KIR3DL1 antikoerper, KIR3DL3 antikoerper, CD158E1 antikoerper, KIR antikoerper, KIR3DL1/S1 antikoerper, NKAT3 antikoerper, NKB1 antikoerper, NKB1B antikoerper, Kirl1 antikoerper, Kirl2 antikoerper, Krl1 antikoerper, killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 antikoerper, uncharacterized LOC100437736 antikoerper, killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 antikoerper, KIR3DL1 antikoerper, LOC100437736 antikoerper, Kir3dl1 antikoerper

Hintergrund: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response.

Cellular Localization: Cell membrane, Single-pass type I membrane protein

Molekulargewicht: 49 kDa

Gen-ID: 3811