PFKM Antikörper (N-Term)

Produktnummer ABIN2854614

Produktdetails anti-PFKM Antikörper

Target: PFKM (phosphofructokinase, Muscle (PFKM))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PFKM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Rabbit Polyclonal antibody to PFK (muscle) (phosphofructokinase, muscle)
PFK (muscle) antibody [N1N2-2], N-term

Aufreinigung: Purified by antigen-affinity chromatography.

Güteklasse: KO Validated

Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human Fructose 6 Phosphate Kinase. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: mouse brain , rat brain , HeLa

Validation: KO/KD

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.52 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu PFKM

Target: PFKM (phosphofructokinase, Muscle (PFKM))

Andere Bezeichnung: phosphofructokinase, muscle (PFKM Produkte)

Synonyme: GSD7 antikoerper, PFK-1 antikoerper, PFK1 antikoerper, PFKA antikoerper, PFKX antikoerper, AI131669 antikoerper, PFK-A antikoerper, PFK-M antikoerper, Pfk-4 antikoerper, Pfk4 antikoerper, Pfka antikoerper, Pfkx antikoerper, Pfk-M antikoerper, M-PFK antikoerper, PFKM antikoerper, pfkm antikoerper, zgc:92344 antikoerper, pfk antikoerper, im:7137110 antikoerper, wu:fc58g11 antikoerper, phosphofructokinase, muscle antikoerper, phosphofructokinase, platelet antikoerper, phosphofructokinase, muscle a antikoerper, phosphofructokinase, muscle S homeolog antikoerper, phosphofructokinase, muscle b antikoerper, PFKM antikoerper, Pfkm antikoerper, PFKP antikoerper, pfkma antikoerper, pfkm.S antikoerper, pfkmb antikoerper

Hintergrund: The PFKM gene encodes the muscle isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. Mammalian PFK is a tetramer made up of various combinations of 3 subunits: muscle (PFKM), liver (PFKL, MIM 171860), and platelet (PFKP, MIM 171840), the genes for which are located on chromosomes 12q13, 21q22, and 10p, respectively. The composition of the tetramers differs according to the tissue type. Muscle and liver PFK are a homotetramers of 4M and 4L subunits, respectively. Erythrocytes contain both L and M subunits, which randomly tetramerize to form M4, L4, and M3L, M2L2, and ML3 hybrid forms of the holoenzyme (Vora et al., 1980 [PubMed 6444721], Raben and Sherman, 1995 [PubMed 7550225]).[supplied by OMIM]

Molekulargewicht: 85 kDa

Gen-ID: 5213

UniProt: P08237

Pathways: Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Warburg Effekt