NQO1 Antikörper (C-Term)

Produktnummer ABIN2854666

Produktdetails anti-NQO1 Antikörper

Target: NQO1 (NAD(P)H Dehydrogenase, Quinone 1 (NQO1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NQO1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Schwein, Rhesusaffen, Rind (Kuh), Meerschweinchen

Kreuzreaktivität (Details): Pig (92 %), Rhesus Monkey (100 %), Bovine (83 %), Guinea pig (100 %)

Produktmerkmale: Rabbit Polyclonal antibody to NQO1 (NAD(P)H dehydrogenase, quinone 1)
NQO1 antibody [C2C3], C-term

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human NQO1. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Suggested dilution Reference ICC/IF 1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*

Kommentare:

Positive Control: Molt-4 , Raji , mouse heart , rat heart

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-NQO1 Antikörper (ABIN2854666)

Ishitsuka, Huebner, Rice, Koch, Speransky, Steven, Roop: "Lce1 Family Members Are Nrf2-Target Genes that Are Induced to Compensate for the Loss of Loricrin." in: The Journal of investigative dermatology, Vol. 136, Issue 8, pp. 1656-1663, (2017) (PubMed).

Details zu NQO1

Target: NQO1 (NAD(P)H Dehydrogenase, Quinone 1 (NQO1))

Andere Bezeichnung: NQO1 (NQO1 Produkte)

Synonyme: zgc:77191 antikoerper, wu:fb63c10 antikoerper, nqo1 antikoerper, DHQU antikoerper, DIA4 antikoerper, DTD antikoerper, NMOR1 antikoerper, NMORI antikoerper, QR1 antikoerper, Dia4 antikoerper, AV001255 antikoerper, Dtd antikoerper, Nmo-1 antikoerper, Nmo1 antikoerper, Nmor1 antikoerper, Ox-1 antikoerper, Ox1 antikoerper, Qr1 antikoerper, NADPH-d antikoerper, NAD(P)H dehydrogenase, quinone 1 antikoerper, NAD(P)H quinone dehydrogenase 1 antikoerper, NAD(P)H dehydrogenase, quinone 1 L homeolog antikoerper, nqo1 antikoerper, NQO1 antikoerper, Bpet2092 antikoerper, nqo1.L antikoerper, Nqo1 antikoerper

Hintergrund: This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Cellular Localization: Cytoplasm

Molekulargewicht: 31 kDa

Gen-ID: 1728