FANCC Antikörper (Center)

Produktnummer ABIN2854743

Produktdetails anti-FANCC Antikörper

Target: FANCC (Fanconi Anemia, Complementation Group C (FANCC))

Bindungsspezifität: Center

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FANCC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Produktmerkmale: Rabbit Polyclonal antibody to FANCC (Fanconi anemia, complementation group C)
FANCC antibody [N1C1]

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human FANCC. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Suggested dilution Reference ICC/IF 1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*

Kommentare:

Positive Control: 293T , A431 , HeLa , HepG2 , NIH-3T3

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.989 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-FANCC Antikörper (ABIN2854743)

Pan, Wang, Chen, Ding, Jiang, Gao, Mo, Huang, Lou, Cao: "Deleterious Mutations in DNA Repair Gene FANCC Exist in BRCA1/2-Negative Chinese Familial Breast and/or Ovarian Cancer Patients." in: Frontiers in oncology, Vol. 9, pp. 169, (2019) (PubMed).

Details zu FANCC

Target: FANCC (Fanconi Anemia, Complementation Group C (FANCC))

Andere Bezeichnung: FANCC (FANCC Produkte)

Synonyme: zgc:154105 antikoerper, FANCC antikoerper, fa3 antikoerper, fac antikoerper, facc antikoerper, FA3 antikoerper, FAC antikoerper, FACC antikoerper, BB116513 antikoerper, Facc antikoerper, Fanconi anemia complementation group C antikoerper, Fanconi anemia, complementation group C antikoerper, Fanconi anemia complementation group C L homeolog antikoerper, FANCC antikoerper, fancc antikoerper, fancc.L antikoerper, Fancc antikoerper

Hintergrund: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity, they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C.

Cellular Localization: Nucleus , Cytoplasm

Molekulargewicht: 63 kDa

Gen-ID: 2176

Pathways: DNA Reparatur