MMP1 Antikörper

Produktnummer ABIN2854783

Produktdetails anti-MMP1 Antikörper

Target: MMP1 (Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MMP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC)

Kreuzreaktivität: Human, Maus

Produktmerkmale: Rabbit Polyclonal antibody to MMP1 (matrix metallopeptidase 1 (interstitial collagenase))
MMP1 antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human MMP1. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Validation: Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.7 mg/mL

Buffer: 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-MMP1 Antikörper (ABIN2854783)

Bordignon, Bottoni, Xu, Popescu, Truan, Guenova, Kofler, Jafari, Ostano, Röcken, Neel, Dotto: "Dualism of FGF and TGF-β Signaling in Heterogeneous Cancer-Associated Fibroblast Activation with ETV1 as a Critical Determinant." in: Cell reports, Vol. 28, Issue 9, pp. 2358-2372.e6, (2020) (PubMed).

Wu, Lin, Hou, Chang, Wen, Lin, Chiang: "1,2-Bis[(3-Methoxyphenyl)Methyl]Ethane-1,2-Dicarboxylic Acid Reduces UVB-Induced Photodamage In Vitro and In Vivo." in: Antioxidants (Basel, Switzerland), Vol. 8, Issue 10, (2019) (PubMed).

Dubey, Wei, Yu, Williams, Wang, Deng, Tsai, Wang, Deng: "Adipose-derived Stem Cells Attenuates Diabetic Osteoarthritis via Inhibition of Glycation-mediated Inflammatory Cascade." in: Aging and disease, Vol. 10, Issue 3, pp. 483-496, (2019) (PubMed).

Olaya-C, Garrido, Hernandez-Losa, Sesé, Ayala-Ramirez, Somoza, Vargas, Ramón Y Cajal: "The umbilical cord, preeclampsia and the VEGF family." in: International journal of women's health, Vol. 10, pp. 783-795, (2018) (PubMed).

Kim, Choi, Lee, Soh, Kim, Park: "Senescent tumor cells lead the collective invasion in thyroid cancer." in: Nature communications, Vol. 8, pp. 15208, (2018) (PubMed).

Details zu MMP1

Target: MMP1 (Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1))

Andere Bezeichnung: matrix metallopeptidase 1 (MMP1 Produkte)

Synonyme: CLG antikoerper, CLGN antikoerper, Mmp1a antikoerper, CG4859 antikoerper, Dm1-MMP antikoerper, Dmel\\CG4859 antikoerper, MMP-1 antikoerper, MMP1 antikoerper, Mmp 1 antikoerper, dMMP1 antikoerper, dm1-MMP antikoerper, dmmp1 antikoerper, l(2)k04809 antikoerper, mmp1 antikoerper, Mmp1 antikoerper, Mcol-A antikoerper, Mcola antikoerper, col4 antikoerper, mmp18 antikoerper, Clgn antikoerper, matrix metallopeptidase 1 antikoerper, Matrix metalloproteinase 1 antikoerper, matrix metalloproteinase 1 antikoerper, matrix metallopeptidase 1 (interstitial collagenase) antikoerper, matrix metallopeptidase 1a (interstitial collagenase) antikoerper, matrix metallopeptidase 1 S homeolog antikoerper, interstitial collagenase antikoerper, matrix metallopeptidase 8 L homeolog antikoerper, MMP1 antikoerper, Mmp1 antikoerper, RB11133 antikoerper, Mmp1a antikoerper, mmp1.S antikoerper, LOC100727966 antikoerper, mmp8.L antikoerper

Hintergrund: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.

Cellular Localization: Secreted , extracellular space , extracellular matrix

Molekulargewicht: 54 kDa

Gen-ID: 4312

UniProt: P03956