MUC2 Antikörper (C-Term)

Produktnummer ABIN2854828

Produktdetails anti-MUC2 Antikörper

Target: MUC2 (Mucin 2, Oligomeric Mucus/gel-Forming (MUC2))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MUC2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Fluorescence in situ hybridization (FISH)

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Rabbit Polyclonal antibody to MUC2 (mucin 2, oligomeric mucus/gel-forming)
MUC2 antibody [C3], C-term

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human MUC2. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Validation: Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-MUC2 Antikörper (ABIN2854828)

Toubai, Fujiwara, Rossi, Riwes, Tamaki, Zajac, Liu, Mathew, Byun, Oravecz-Wilson, Matsuda, Sun, Peltier, Wu, Chen, Seregin, Henig, Kim, Brabbs, Pennathur, Chen, Reddy: "Host NLRP6 exacerbates graft-versus-host disease independent of gut microbial composition." in: Nature microbiology, Vol. 4, Issue 5, pp. 800-812, (2019) (PubMed).

Details zu MUC2

Target: MUC2 (Mucin 2, Oligomeric Mucus/gel-Forming (MUC2))

Andere Bezeichnung: mucin 2, oligomeric mucus/gel-forming (MUC2 Produkte)

Synonyme: 2010015E03Rik antikoerper, MCM antikoerper, wnn antikoerper, MLP antikoerper, MUC-2 antikoerper, SMUC antikoerper, HH-Muc antikoerper, mucin 2 antikoerper, mucin 2, oligomeric mucus/gel-forming antikoerper, mucin-2 antikoerper, Muc2 antikoerper, MUC2 antikoerper, LOC100724045 antikoerper

Hintergrund: This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80 % is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Cellular Localization: Secreted

Molekulargewicht: 540 kDa

Gen-ID: 4583

UniProt: Q02817