MMP13 Antikörper

Produktnummer ABIN2854829

Produktdetails anti-MMP13 Antikörper

Target: MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MMP13 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Rabbit Polyclonal antibody to MMP13 (matrix metallopeptidase 13 (collagenase 3))
MMP13 antibody [N3C1], Internal

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human MMP13. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: NT2D1

Validation: Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-MMP13 Antikörper (ABIN2854829)

Nakagawa, Lebaschi, Wada, Green, Wang, Album, Carballo, Deng, Rodeo: "Duration of postoperative immobilization affects MMP activity at the healing graft-bone interface: Evaluation in a mouse ACL reconstruction model." in: Journal of orthopaedic research : official publication of the Orthopaedic Research Society, Vol. 37, Issue 2, pp. 325-334, (2019) (PubMed).

Details zu MMP13

Target: MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))

Andere Bezeichnung: matrix metallopeptidase 13 (MMP13 Produkte)

Synonyme: CLG3 antikoerper, MANDP1 antikoerper, Clg antikoerper, MMP-13 antikoerper, Mmp1 antikoerper, cb1034 antikoerper, mmp13 antikoerper, gene A antikoerper, xCol antikoerper, xcl3 antikoerper, MMP13 antikoerper, MGC108008 antikoerper, matrix metallopeptidase 13 antikoerper, matrix metallopeptidase 13a antikoerper, matrix metallopeptidase 13 (collagenase 3) like S homeolog antikoerper, matrix metallopeptidase 13 (collagenase 3) antikoerper, matrix metalloproteinase 13 antikoerper, matrix metallopeptidase 13 (collagenase 3) like L homeolog antikoerper, MMP13 antikoerper, Mmp13 antikoerper, mmp13a antikoerper, mmp13l.S antikoerper, mmp13 antikoerper, LOC100136348 antikoerper, mmp13l.L antikoerper

Hintergrund: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Cellular Localization: Secreted , extracellular space , extracellular matrix

Molekulargewicht: 54 kDa

Gen-ID: 4322

UniProt: P45452