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KNG1 Antikörper

KNG1 Reaktivität: Human WB, ICC, IHC (p), IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2854874
  • Target Alle KNG1 Antikörper anzeigen
    KNG1 (Kininogen 1 (KNG1))
    Reaktivität
    • 59
    • 12
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 62
    • 9
    • 4
    Kaninchen
    Klonalität
    • 68
    • 7
    Polyklonal
    Konjugat
    • 48
    • 6
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser KNG1 Antikörper ist unkonjugiert
    Applikation
    • 53
    • 37
    • 31
    • 11
    • 8
    • 7
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Kreuzreaktivität
    Human
    Produktmerkmale
    Rabbit Polyclonal antibody to HMW Kininogen (kininogen 1)
    HMW Kininogen antibody
    Aufreinigung
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human HMW Kininogen. The exact sequence is proprietary.
    Isotyp
    IgG
    Top Product
    Discover our top product KNG1 Primärantikörper
  • Applikationshinweise
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Kommentare

    Positive Control: Molt-4

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
    Konservierungsmittel
    Thimerosal (Merthiolate)
    Vorsichtsmaßnahmen
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    KNG1 (Kininogen 1 (KNG1))
    Andere Bezeichnung
    kininogen 1 (KNG1 Produkte)
    Synonyme
    BDK antikoerper, BK antikoerper, KNG antikoerper, Kng antikoerper, KNG2 antikoerper, fb64g01 antikoerper, wu:fb64g01 antikoerper, zgc:103569 antikoerper, kininogen antikoerper, bdk antikoerper, kng antikoerper, KNG1 antikoerper, IHRP antikoerper, KINKG antikoerper, KINKH antikoerper, Kng1 antikoerper, Kngk antikoerper, kininogen 1 antikoerper, kininogen 1 L homeolog antikoerper, inter-alpha-trypsin inhibitor heavy chain family member 4 antikoerper, kininogen 2-like 1 antikoerper, KNG1 antikoerper, Kng1 antikoerper, kng1 antikoerper, kng1.L antikoerper, ITIH4 antikoerper, Kng2l1 antikoerper
    Hintergrund
    High molecular weight kininogen (HMWK) plays an important role in assembly of the plasma kallikrein (see MIM 147910)-kinin system. The KNG1 gene generates both HMWK and low molecular weight kininogen (LMWK) through alternative splicing. Both HMWK and LMWK contain an identical heavy chain consisting of protein domains 1, 2, and 3. However, HMWK contains a 56-kD light chain that consists of domains 5 and 6H, whereas LMWK contains a unique 4-kD light chain that consists of domain 5L. In both proteins, the heavy and light chains are linked by domain 4, which contains the bradykinin (BK) nonapeptide. BK, which is released by plasma kallikrein, is a potent inflammatory mediator that causes vasodilation and enhanced capillary permeability, induces pain, and stimulates production of nitric oxide and prostacyclin (see MIM 601699) from endothelial cells. During vascular damage, BK stimulates smooth muscle proliferation and intimal hypertrophy. Release of BK from HMWK generates a 2-chain HMWK, termed HMWKa, containing the heavy and light chains joined by a disulfide bond (Merkulov et al., 2008 [PubMed 18000168]).[supplied by OMIM]

    Molekulargewicht
    72 kDa
    Gen-ID
    3827
    UniProt
    P01042
    Pathways
    ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process
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