PRKG1 Antikörper (Center)
-
- Target Alle PRKG1 Antikörper anzeigen
- PRKG1 (Protein Kinase, CGMP-Dependent, Type I (PRKG1))
-
Bindungsspezifität
- Center
-
Reaktivität
- Human, Maus
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser PRKG1 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Produktmerkmale
-
Rabbit Polyclonal antibody to cGK1 (protein kinase, cGMP-dependent, type I)
cGK1 antibody - Aufreinigung
- Purified by antigen-affinity chromatography.
- Immunogen
- Recombinant protein encompassing a sequence within the center region of human cGK1. The exact sequence is proprietary.
- Isotyp
- IgG
- Top Product
- Discover our top product PRKG1 Primärantikörper
-
-
- Applikationshinweise
- Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*
- Kommentare
-
Positive Control: NIH-3T3 , JC
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
- Konservierungsmittel
- Thimerosal (Merthiolate)
- Vorsichtsmaßnahmen
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
-
- Target
- PRKG1 (Protein Kinase, CGMP-Dependent, Type I (PRKG1))
- Andere Bezeichnung
- cGK1 (PRKG1 Produkte)
- Synonyme
- prkg1 antikoerper, zgc:63955 antikoerper, Pkgi antikoerper, cGk1 antikoerper, 1 antikoerper, PKG antikoerper, PRKG1B antikoerper, PRKGR1B antikoerper, cGK antikoerper, cGK 1 antikoerper, cGK1 antikoerper, cGKI antikoerper, cGKI-BETA antikoerper, cGKI-alpha antikoerper, CGKI antikoerper, cGKI-beta antikoerper, AW125416 antikoerper, Gm19690 antikoerper, Prkg1b antikoerper, Prkgr1b antikoerper, Prkg1beta antikoerper, protein kinase, cGMP-dependent, type Ia antikoerper, protein kinase, cGMP-dependent, type I antikoerper, protein kinase, cGMP-dependent, type 1 antikoerper, prkg1a antikoerper, PRKG1 antikoerper, prkg1 antikoerper, Prkg1 antikoerper
- Hintergrund
-
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]
- Molekulargewicht
- 76 kDa
- Gen-ID
- 5592
-