PPARA Antikörper (N-Term)

Produktnummer ABIN2854934

Produktdetails anti-PPARA Antikörper

Target: PPARA (Peroxisome Proliferator-Activated Receptor alpha (PPARA))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPARA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Chromatin Immunoprecipitation (ChIP)

Kreuzreaktivität: Bee, Human, Maus, Pflanzen, Ratte

Produktmerkmale: Rabbit Polyclonal antibody to PPAR alpha (peroxisome proliferator-activated receptor alpha)
PPAR alpha antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Güteklasse: KO Validated

Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human PPAR alpha. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Validation: KO/KD, Orthogonal, Overexpression

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.39 mg/mL

Buffer: 1XPBS pH 7, 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-PPARA Antikörper (ABIN2854934)

Kubo, Hoshi, Matsumoto, Irie, Oura, Tsutsumi, Hata, Yamamoto, Saito: "Sake lees extract improves hepatic lipid accumulation in high fat diet-fed mice." in: Lipids in health and disease, Vol. 16, Issue 1, pp. 106, (2018) (PubMed).

Song, Qu, Zhang, Jiang, Zhou, Jiang, Li, Zhang, Yan: "Phytosterol esters attenuate hepatic steatosis in rats with non-alcoholic fatty liver disease rats fed a high-fat diet." in: Scientific reports, Vol. 7, pp. 41604, (2018) (PubMed).

Chung, Liu, Lin, Chi, Huang, Yang, Yeh, Tan, Lin: "ChIP-on-chip analysis of thyroid hormone-regulated genes and their physiological significance." in: Oncotarget, Vol. 7, Issue 16, pp. 22448-59, (2017) (PubMed).

Details zu PPARA

Target: PPARA (Peroxisome Proliferator-Activated Receptor alpha (PPARA))

Andere Bezeichnung: peroxisome proliferator activated receptor alpha (PPARA Produkte)

Synonyme: NR1C1 antikoerper, PPAR antikoerper, PPARalpha antikoerper, hPPAR antikoerper, LOC100136415 antikoerper, PPARALPHA antikoerper, nr1c1 antikoerper, xPPARalpha antikoerper, xppara antikoerper, 4933429D07Rik antikoerper, AW742785 antikoerper, Nr1c1 antikoerper, PPAR-alpha antikoerper, Ppar antikoerper, peroxisome proliferator activated receptor alpha antikoerper, peroxisome proliferator-activated receptor alpha antikoerper, peroxisome proliferator activated receptor alpha L homeolog antikoerper, PPARA antikoerper, LOC100136415 antikoerper, ppara.L antikoerper, Ppara antikoerper, ppara antikoerper

Hintergrund: Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers, this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.

Molekulargewicht: 52 kDa

Gen-ID: 5465

UniProt: Q07869

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process, Hepatitis C